BioCentury | Nov 13, 2018
Distillery Techniques

Disease models

...and knockouts miR-378-deficient mice could be used to screen therapies for muscular dystrophy. Mice with miR-378...
...muscular dystrophy. Next steps could include using the model to screen for therapies. DESCRIPTION: MicroRNA-378 (miR-378)-deficient...
...CONTACT: Hao Ying, Chinese Academy of Sciences, Shanghai, China email: yinghao@sibs.ac.cn Chris Lieu Chinese Academy of Sciences MicroRNA-378 (miR-378) Muscular...
BioCentury | Apr 4, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: March 2018

...Distillery Therapeutics Melanoma MicroRNA-378-3p (miR-378-3p) Studies in patient samples, cell culture and mice suggest a miR-378-3p...
BioCentury | Mar 13, 2018
Distillery Therapeutics

Cancer

INDICATION: Melanoma Studies in patient samples, cell culture and mice suggest a miR-378a-3p variant or inhibiting its target PARVA could help treat melanoma. In patients, high tumor levels of PARVA were associated with poor survival....
BioCentury | Sep 27, 2012
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...inhibiting miR-378 could help prevent obesity and metabolic syndrome. In mice, deletion of miR-378 and miR-378*...
...increased resistance to diet-induced obesity compared with normal expression of the miRNAs. In miR-378 and miR-378*...
...developing compounds to inhibit miR-378 signaling. miRagen Therapeutics Inc. has a preclinical program to validate miR-378...
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