22:51 , Nov 13, 2018 |  BC Innovations  |  Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockouts miR-378-deficient mice could be used to screen therapies for muscular dystrophy. Mice with miR-378 knocked out recapitulated the low muscle weight, poor motor performance, defects in autophagy, mitochondrial abnormalities and skeletal...
07:00 , Sep 27, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine/metabolic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine/metabolic disease Metabolic syndrome; obesity MicroRNA-378 (miR-378); miR-378* Mouse studies suggest inhibiting miR-378 could help prevent obesity and metabolic syndrome. In mice, deletion of miR-378 and...