23:05 , Aug 1, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: July 2018

New Therapeutic Targets and Biomarkers: July 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during July 2018. Therapeutic targets are defined as any protein, gene or other molecule...
21:37 , Jul 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Cell culture studies suggest promoting interactions between miR-34a and tRNA-iMet could help treat breast cancer. In a panel of human breast cancer cell lines, levels of miR-34a were lower and levels of its...
20:32 , Nov 6, 2017 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Bronchopulmonary dysplasia (BPD); acute lung injury Patient sample, mouse and cell culture studies suggest inhibiting miR-34a could help treat BPD and acute lung injury (ALI) in neonates. In postmortem lung tissue samples from premature infants...
21:32 , Sep 21, 2017 |  BC Innovations  |  Translation in Brief

No vehicle, no problem

A Purdue University team has developed a ligand-targeted method to deliver microRNA (miRNA) mimics to tumors without relying on vehicles or compromising miRNA processing. The researchers think their folate receptor-targeted miRNAs, or “FolamiRs,” could widen...
19:20 , Sep 19, 2017 |  BC Innovations  |  Distillery Techniques

Drug delivery

TECHNOLOGY: Targeting domains A folate receptor-targeted system could help deliver therapeutic miRNA mimics to folate receptor-expressing cancers. The delivery system involves generating an miRNA passenger strand containing 2'-O-methyl-modified bases to enhance stability, conjugating its 5' end...
18:09 , Jul 10, 2017 |  BC Innovations  |  Distillery Therapeutics

Autoimmune disease

INDICATION: Rheumatoid arthritis (RA) Patient sample and mouse studies suggest inhibiting miR-34a could help treat RA. In dendritic cells (DCs) in synovial tissue samples from patients, levels of miR-34a were higher than in DCs in peripheral...
07:00 , Oct 9, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Liver cancer MicroRNA-34a (miR-34a) Mouse and cell culture studies identified a new small molecule that could help...
07:00 , Sep 11, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Lung cancer K-Ras (KRAS); microRNA-34a (miR-34a) Mouse studies suggest nanoparticle delivery of siRNAs targeting KRAS and miR-34a...
07:00 , Mar 14, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Myocardial infarction (MI) MicroRNA-34a (miR-34a); protein phosphatase 1 regulatory subunit 10 (PPP1R10) Patient tissue and...
07:00 , Oct 18, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Myocardial infarction (MI) MicroRNA-34a (miR-34a); miR-34b; miR-34c Mouse studies suggest locked nucleic acids (LNAs) that...