BioCentury | Jun 20, 2018
Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Levels of miR-301a in serum-derived exosomes could help diagnose and predict progression in pancreatic cancer. In serum-derived exosomes from 50 patients, miR-301a levels were higher than in serum-derived exosomes from 12 healthy...
BioCentury | Feb 28, 2017
Distillery Therapeutics

Infectious disease

INDICATION: Encephalitis Cell culture and mouse studies suggest inhibiting miR-301a could help treat Japanese encephalitis (JE). In a mouse hippocampal cell line infected with JE virus, knockdown of miR-301a decreased viral replication compared with normal...
BioCentury | Sep 1, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-301b (miR-301b); interleukin-4 (IL-4) (BSF1); transforming growth factor β 1 (TGFβ1)

Infectious disease INDICATION: Bacterial infection; Gram-negative bacterial infection; Pseudomonas; Streptococcus Cell culture and mouse studies suggest that inhibiting the expression of miR-301b could help treat Pseudomonas, Streptococcus and other Gram-negative bacterial infections. In lipopolysaccharide (LPS)-pretreated...
BioCentury | Dec 17, 2015
Distillery Therapeutics

Therapeutics: MicroRNA-130 (miR-130); miR-301

...Cardiovascular disease INDICATION: Hypertension In vitro and rodent studies suggest inhibiting the miR-130 / miR-301 family...
...stiffness increased miR-130/301 expression, collagen deposition, vascular matrix remodeling and created a feed-forward loop of miR-130/miR-301...
...additional inhibitors of the miR-130/301 pathway in animal models of PAH. TARGET/MARKER/PATHWAY: MicroRNA-130 (miR-130) ; miR-301...
BioCentury | Jul 31, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...disease Hypertension MicroRNA-130 (miR-130); miR-301 Studies in human samples and mice suggest inhibiting miR-130- and miR-301-family...
...both mouse models of experimental PH and patients, expression of miRNAs in the miR-130 and miR-301...
...anti-miRNAs. Next steps include developing an antisense oligonucleotide inhibitor effective against the entire miR-130 and miR-301...
BioCentury | May 10, 2012
Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) MicroRNA-301a (miR-301a) A study in mice suggests antagonizing miR-301a could help treat MS. In an experimental autoimmune encephalomyelitis (EAE) mouse model...
BioCentury | Jan 6, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer MicroRNA-301a (miR-301a); NF-kB In vitro and mouse studies suggest that inhibiting miR-301a could help treat pancreatic cancer. In vitro, miR-301a activated expression of...
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