BioCentury | Apr 5, 2019
Tools & Techniques

Second shot for shRNA

...superfamily member 17 CCR5 (CD195) - CC chemokine receptor 5 CD3ζ (CD247) miR-30 - MicroRNA-30 miR-196a...
BioCentury | Jul 14, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-196b (miR-196b)

Cancer INDICATION: Lung cancer Patient sample, cell culture and mouse studies suggest miR-196b could help treat lung cancer. Levels of inactive, methylated miR-196b were higher in sputum samples from lung cancer patients than in samples...
BioCentury | Aug 20, 2015
Distillery Therapeutics

Therapeutics: MicroRNA-196a (miR-196a); v-myc myelocytomatosis viral oncogene homolog (MYC; c-Myc); homeobox B7 (HOXB7)

...Cancer INDICATION: Breast cancer Studies in patient samples, cell culture and mice suggest miR-196a or inhibition...
...breast cancer cell lines, knockdown or pharmacological inhibition of MYC decreased HOXB7 levels and increased miR-196a...
...cancer, vector-mediated overexpression of miR-196a increased tumor responses to tamoxifen. Next steps could include combining miR-196a...
BioCentury | Jan 30, 2014
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML) MicroRNA-196b (miR-196b); miR-21 Patient sample, mouse and in vitro studies suggest inhibiting miR-196b and miR-21 could help...
BioCentury | Aug 8, 2013
Distillery Therapeutics

Indication: Neurology

...miR-196a overexpression decreased HD-associated motor deficits and tissue pathology in the brain compared with normal miR-196a...
...compared with no miR-196a. Next steps include developing a methodology for in vivo delivery of miR-196a...
BioCentury | Jun 28, 2012
Distillery Therapeutics

Indication: Neurology

...miR-196a could help treat SBMA. In cell culture, an adeno-associated virus (AAV) vector bearing transgenic miR-196a...
...androgen receptor, which causes SBMA. In a mouse model of SBMA, peripheral injection of an miR-196a-expressing...
BioCentury | Feb 16, 2012
Distillery Therapeutics

Indication: Cancer

...Gastrointestinal cancer MicroRNA-196a (miR-196a); HOX transcript antisense RNA (HOTAIR) Patient sample and cell culture studies suggest miR-196a...
...could be prognostic markers or therapeutic targets for gastrointestinal cancer. Patients with high levels of miR-196a...
...decreased cell viability and invasion compared with control siRNA. Next steps include measuring levels of miR-196a...
BioCentury | Jun 1, 2009
Emerging Company Profile

Asuragen: Cutting pancreatic surgeries

...Asuragen's researchers reported on the use of quantitative reverse-transcription PCR to measure two miRNA markers: miR-196a...
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