07:00 , Jun 30, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: A 15-microRNA (miRNA) signature to predict survival in patients with colon, pancreatic and stomach cancers

Biomarkers TECHNOLOGY: Gene profiling A 15-microRNA signature associated with high doublecortin-like kinase 1 (DCLK1) activity could help predict survival in colon, pancreatic and stomach cancers. In colon, esophageal, pancreatic, rectal and stomach tumor samples from...
07:00 , Jun 9, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: MicroRNA-192 (miR-192)

Cancer INDICATION: Pancreatic cancer Patient sample, cell culture and mouse studies suggest promoting miR-192 expression could help treat pancreatic ductal adenocarcinoma (PDAC). In PDAC patients, low tumor levels of miR-192 correlated with poor survival. In...
07:00 , Sep 12, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Disease models

This week in techniques Approach Summary Licensing status Publication and contact information Disease models Engineered influenza A virus with ferret-specific replication An engineered influenza A virus that replicates only in ferrets could help study transmission...
07:00 , Sep 12, 2013 |  BC Innovations  |  Tools & Techniques

Molecular biocontainment for the flu

A team from the Icahn School of Medicine at Mount Sinai and the University of Maryland, College Park has engineered a flu virus that is transmissible among ferrets but not humans. 1 The microRNA-based containment...
07:00 , Oct 28, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Multiple myeloma (MM) MicroRNA-192 (miR-192); miR-194; miR-215; MDM2 p53 binding protein homolog (MDM2; HDM2) Cell culture and mouse studies suggest that p53-regulated miRNAs could help...