BioCentury | May 8, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2019

New Therapeutic Targets and Biomarkers: April 2019 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during April. Therapeutic targets are defined as any protein, gene or other molecule...
BioCentury | Apr 30, 2019
Distillery Therapeutics

miR-19a and miR-19b and their mimics for myocardial infarction

...fibrosis and cardiomyopathy compared with normal miR-19a and miR-19b expression. Also in the model, an miR-19...
BioCentury | Apr 13, 2015
Company News

Regulus Therapeutics Inc, AstraZeneca deal

...develop and commercialize preclinical miRNA therapeutics against three targets. AZ has selected two: miR-103/107 and microRNA-19...
BioCentury | Apr 8, 2015
Company News

AZ picks Regulus' microRNA compound for NASH

...develop and commercialize preclinical microRNA therapeutics against three targets. AZ has selected two: miR-103/107 and microRNA-19...
BioCentury | Dec 4, 2014
Distillery Therapeutics

Indication: Inflammation

Indication Target/marker/pathway Summary Licensing status Publication and contact information Inflammation Allergy; asthma MicroRNA-19a (miR-19a) Studies in mice and patient samples suggest inhibition of miR-19a could help treat asthma. In bronchoalveolar lavage from patients with asthma,...
BioCentury | Mar 10, 2014
Company News

Regulus, AstraZeneca deal

...right to substitute a new target for miR-33. Also in its earnings announcement, Regulus disclosed miR-19...
BioCentury | Dec 19, 2013
Distillery Therapeutics

Indication: Cancer

...but not in normal cerebellum cells. In a mouse xenograft model of medulloblastoma, anti-miR-17 and anti-miR-19...
BioCentury | Mar 4, 2010
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Acute lymphoblastic leukemia (ALL) MicroRNA-19 (miR-19...
...that antagonizing miR-19 could help treat T cell-ALL. In T cell samples from ALL patients, miR-19...
...ongoing testing of miR-19 antagomirs and testing the therapeutic potential of using PI3K-Akt-targeting drugs in miR-19-overexpressing...
BioCentury | Sep 18, 2008
Distillery Therapeutics

This Week in Therapeutics

...This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Ataxia MicroRNA-19...
BioCentury | Aug 28, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Multiple myeloma (MM) microRNA-19a; miRNA-19b; miRNA-21; miRNA-106b~25 cluster; miRNA-181a; miRNA-181b In vitro studies identified multiple miRNAs that could be targeted...
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