BioCentury | May 23, 2018
Distillery Techniques

Assays and screens; biomarkers

...cancer patients and healthy volunteers, the method identified 12 miRNAs -- including miR-122, miR-483-5p and miR-186-5p...
...2018 doi:10.1158/0008-5472.CAN-17-3703 CONTACT: David Issadore, University of Pennsylvania, Philadelphia, Pa. email: daveissadore@gmail.com Sandi Wong University of Pennsylvania MicroRNA-122 (miR-122) MicroRNA-186-5p (miR-186-5p) MicroRNA-483-5p...
BioCentury | Jan 28, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-186-5p (miR-186-5p); chemokine CXC motif ligand 13 (CXCL13); CXC chemokine receptor 5 (CXCR5)

...Neurology INDICATION: Pain Mouse studies suggest promoting miR-186-5p expression or inhibiting CXCL13- CXCR5 signaling could help...
...A mouse model of spinal nerve ligation-induced neuropathic pain had lower spinal cord levels of miR-186-5p...
...Next steps could include identifying CXCL13 or CXCR5 inhibitors or developing an miR-186-5p-based therapeutic. TARGET/MARKER/PATHWAY: MicroRNA-186-5p (miR-186-5p)...
Items per page:
1 - 2 of 2