BC Innovations | Jun 26, 2019
Distillery Therapeutics

miR-17-92 gene therapy for ALS associated with SOD1 mutations

DISEASE CATEGORY: Neurology INDICATION: Amyotrophic lateral sclerosis (ALS) A study from Taiwan's Academia Sinica suggests gene therapies encoding the miR-17-92 cluster could help treat SOD1-associated ALS. The cluster was previously reported to promote survival of...
BC Innovations | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
BC Innovations | Apr 20, 2017
Product R&D

Selectivity suite

Although the small molecule landscape has been largely defined by protein-binding agents, new classes of compounds are emerging that block the formation of specific proteins at the level of their RNA, redefining what constitutes a...
BC Innovations | Dec 19, 2013
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Brain cancer MicroRNA-17-92 (miR-17-92) Cell culture and mouse studies suggest inhibiting miR-17-92 could help treat medulloblastoma. In a mouse model of medulloblastoma, miRNAs from the...
BC Innovations | May 3, 2012
Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Microarray of modified RNAs to identify therapeutic RNAs against folded RNA targets A microarray displaying a library of modified RNAs could help identify therapeutics...
BC Innovations | Sep 1, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Retinoblastoma MicroRNA-17-92 (miR-17-92); miR-17; miR-20 Patient sample and mouse studies suggest inhibiting miRNAs encoded by the miR-17-92 cluster could help treat retinoblastoma. In patient samples,...
BC Innovations | Feb 28, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity miR-17-92 cluster (including miR-17-5p, miR-17-3p, miR-18, miR-19b, miR-20); retinoblastoma 2 (Rb2/p130) A study in cell culture suggests targeting the...
Items per page:
1 - 7 of 7