BioCentury | May 28, 2020
Distillery Therapeutics

microRNA cluster identified as targets for ischemic stroke

...DISEASE CATEGORY: Neurology INDICATION: Stroke Targeting the miR-15a/miR-16-1 cluster to enhance blood-brain barrier function could treat...
...cell surface protein involved in maintaining paracellular barriers and regulating permeability. TARGET/MARKER/PATHWAY: MicroRNA-15a (miR-15a); microRNA-16-1 (miR-16-1...
...Yin, University of Pittsburgh School of Medicine, Pittsburgh, Pa. email: yink2@upmc.edu Claire Quang University of Pittsburgh MicroRNA-15a (miR-15a) MicroRNA-16-1 (miR-16-1) Claudin...
BioCentury | May 9, 2018
Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers Serum levels of miR-940, miR-451a, miR-16-5p and miR-17-3p could help predict response to Herceptin trastuzumab in HER2 (EGFR2; ErbB2; neu)-positive metastatic breast cancer patients. In 283 HER2-positive metastatic breast cancer patients receiving...
BioCentury | Oct 10, 2017
Distillery Therapeutics

Cancer

INDICATION: Melanoma Patient sample, cell culture and mouse studies suggest blocking the interaction of miR-16 and TYRP1 mRNA could help treat melanoma. In melanoma patients, the absence of the low-expressing TYRP1-A allele in tumors was...
BioCentury | Dec 8, 2014
Clinical News

TargomiRs: Phase I started

EnGeneIC and the Asbestos Diseases Research Institute began the open-label, dose-escalation, Australian Phase I MesomiR-1 trial to evaluate IV TargomiRs in up to 22 patients with MPM who failed to respond to standard of care...
BioCentury | Apr 10, 2008
Distillery Therapeutics

This Week in Therapeutics

...This week in therapeutics Cancer Chronic lymphocytic leukemia (CLL) miR-15a; miR-16-1 A study of a leukemia...
...coexpressed gene signature that could be useful for diagnosing CLL. The two microRNAs, miR-15a and miR-16-1...
...downregulated antiapoptotic proteins. The researchers are testing the efficacy of i.v. administration of miR-15a and miR-16-1...
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