BioCentury | Jun 30, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-150 (miR-150); FMS-like tyrosine kinase 3 (FLT3; CD135); FMS-like tyrosine kinase 3 ligand (FLT3LG)

...Cancer INDICATION: Acute myelogenous leukemia (AML); leukemia Patient sample, cell culture and mouse studies suggest miR-150...
...negative regulator of FLT3 , could help treat FLT3-driven AML and mixed lineage leukemia (MLL). miR-150...
...volunteers. In mononuclear bone marrow cells from patients with FLT3-driven AML, polymer nanoparticles loaded with miR-150...
BioCentury | Oct 8, 2015
Distillery Therapeutics

Therapeutics: MicroRNA-150 (miR-150)

...mouse studies suggest miR-150 could help treat retinopathy and other ophthalmic diseases involving pathologic neovascularization. miR-150...
...model of oxygen-induced proliferative retinopathy than in normal mice. In human retinal microvascular endothelial cells, miR-150...
...mimetic. Next steps could include testing miR-150 in additional animal models of pathologic neovascularization. TARGET/MARKER/PATHWAY: MicroRNA-150 (miR-150)...
BioCentury | Dec 12, 2013
Distillery Techniques

Technology: Drug delivery

...B cells were harvested and transfected with a plasmid encoding an antisense RNA sequence against microRNA-150 (miR-150)...
...knockdown of miR-150 activity in T cells. Next steps include characterizing the functional effects of miR-150...
BioCentury | Dec 12, 2013
Tools & Techniques

Plan B for anti-miRNA

...a plasmid encoding a 22-base-pair sequence that was complementary and thus antagonistic to miR-150 . miR-150...
...exosomes. As a result, anti-miR-150 penetrated into the T cells and knocked down expression of miR-150...
...cells from the spleens of mice that received anti-miR-150-transfected B cells had about 60% lower miR-150...
Items per page:
1 - 4 of 4