BioCentury | Apr 13, 2018
Targets & Mechanisms

Hello RNA

BioCentury’s analysis of new and emerging targets presented at this year’s AACR meeting reveals a surge in activity in non-coding RNAs, as researchers continue to expand target space. The results also reflect the ongoing high...
BioCentury | Jul 28, 2016
Distillery Therapeutics

Therapeutics: MicroRNA-125b-5p (miR-125b-5p)

...Hepatic disease INDICATION: Liver failure Patient sample, cell culture and mouse studies suggest miR-125b-5p could help... treat acute liver failure caused by acetaminophen and other toxins. In liver tissue samples, miR-125b-5p...
...could include testing miR-125b-5p in animal models of liver failure caused by other toxins. TARGET/MARKER/PATHWAY: MicroRNA-125b-5p (miR-125b-5p)...
BioCentury | Jun 30, 2016
Distillery Techniques

Techniques: A 15-microRNA (miRNA) signature to predict survival in patients with colon, pancreatic and stomach cancers

Biomarkers TECHNOLOGY: Gene profiling A 15-microRNA signature associated with high doublecortin-like kinase 1 (DCLK1) activity could help predict survival in colon, pancreatic and stomach cancers. In colon, esophageal, pancreatic, rectal and stomach tumor samples from...
BioCentury | Dec 18, 2014
Distillery Techniques

Techniques: MicroRNA let-7c (MIRLET7C; let-7c), microRNA-99a (miR-99a) and microRNA-125b (miR-125b) as prognostic markers of luminal breast cancer

Bio Markers TECHNOLOGY: Markers Studies in patient samples and cell culture suggest let-7c , miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor-positive luminal breast cancers. MicroRNA profiling showed that levels of...
BioCentury | Oct 7, 2010
Targets & Mechanisms

An miRNA boost for p53

Although many studies have shown that altered expression of one or more microRNAs is associated with cancer, they have not shown that the miRNAs could be therapeutically targeted with a drug-like molecule. Now, U.S. and...
BioCentury | Mar 26, 2009
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Cancer microRNA-125b (miRNA-125b) Studies in cell culture and in zebrafish suggest that inhibiting miRNA-125b could be useful for treating cancer....
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