BC Innovations | Jan 15, 2019
Distillery Therapeutics

Infectious disease

INDICATION: Zika virus Mouse and non-human primate (NHP) studies suggest a live-attenuated vaccine engineered to express sequences targeted by four miRNAs specific to brain, testis or epididymis tissues could help prevent Zika viral infection. The...
BC Innovations | Sep 27, 2018
Translation in Brief

Twice as splice

Abivax S.A. (Euronext:ABVX) has positioned its anti-HIV therapy ABX464 to take on inflammatory diseases after discovering the small molecule triggers RNA splicing that both halts HIV viral replication and boosts anti-inflammatory responses in HIV and...
BC Week In Review | Sep 7, 2018
Clinical News

Abivax's ABX464 improves mucosal healing, Mayo Score in Phase IIa for UC

Abivax S.A. (Euronext:ABVX) said ABX464 improved mucosal healing rate (50% vs. 11%, p=0.03) and reduced partial (62% vs. 32%, p<0.02) and total Mayo Scores (53% vs. 37%, p<0.03) at eight weeks vs. placebo in 29...
BC Innovations | Dec 10, 2015
Distillery Therapeutics

Therapeutics: MicroRNA-124 (miR-124)

Cancer INDICATION: Prostate cancer Mouse studies suggest miR-124 could help treat castration-resistant prostate cancer (CRPC). In human prostate cancer cell lines, miR-124 plus Xtandi enzalutamide or Casodex bicalutamide decreased proliferation compared with either agent alone....
BC Innovations | Nov 20, 2014
Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Direct reprogramming of human fibroblasts to striatal medium spiny neurons (MSNs) Direct reprogramming of human fibroblasts to human striatal neurons could help generate new cellular...
BC Innovations | Dec 15, 2011
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Liver cancer Hepatocyte nuclear factor 4a (HNF4A; TCF); microRNA-124 (miR-124) Mouse and patient sample studies suggest increasing signaling in the HNF4A-miR-124 pathway could help treat...
BC Innovations | Aug 18, 2011
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Direct conversion of fibroblasts into functional neurons A method for directly converting human fibroblasts into functional neurons could be useful for...
BC Innovations | Jan 13, 2011
Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) MicroRNA-124 (miR-124) In vitro and mouse studies suggest that miR-124 could help treat MS. In a mouse...
BC Innovations | Jun 24, 2010
Tools & Techniques

Pitting one virus against another

Mount Sinai School of Medicine 's Benjamin tenOever has devoted most of his research to developing vaccines for influenza and other RNA viruses. Now, his team has decided to put the influenza virus to work...
BC Innovations | Jun 17, 2010
Distillery Techniques

Technology: Drug delivery

Approach Summary Licensing status Publication and contact information Drug delivery Viral RNA-mediated delivery of RNA-based therapeutics In vitro studies suggest that influenza A and other RNA viruses could be useful for delivering microRNAs to treat...
Items per page:
1 - 10 of 10