BioCentury | Nov 15, 2019
Product Development

Chipping away at unreliable animal data

...models, the Liver-Chips are designed to assess clinically relevant endpoints and safety biomarkers including high microRNA-122...
BioCentury | May 23, 2018
Distillery Techniques

Assays and screens; biomarkers

...samples from pancreatic cancer patients and healthy volunteers, the method identified 12 miRNAs -- including miR-122...
...2018 doi:10.1158/0008-5472.CAN-17-3703 CONTACT: David Issadore, University of Pennsylvania, Philadelphia, Pa. email: daveissadore@gmail.com Sandi Wong University of Pennsylvania MicroRNA-122 (miR-122) MicroRNA-186-5p...
BioCentury | Feb 3, 2017
Clinical News

RG-101 regulatory update

...Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Product: RG-101 , Anti-miR-122 Business: Infectious Julian Zhu RG-101 Regulus Therapeutics Inc. MicroRNA-122 (miR-122...
BioCentury | Aug 15, 2016
Clinical News

RG-101 regulatory update

...a GalNAc-conjugated antagonist targeting miR-122. Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif. Product: RG-101 , Anti-miR-122...
BioCentury | Jul 18, 2016
Clinical News

RG-101: Additional Phase II data

...Calif. Product: RG-101 , Anti-miR-122 Business: Infectious Molecular target: MicroRNA-122 (miR-122) Description: GalNAc-conjugated antagonist targeting miR-122...
BioCentury | Jul 11, 2016
Clinical News

RG-101: FDA hold

...Calif. Product: RG-101 , Anti-miR-122 Business: Infectious Molecular target: MicroRNA-122 (miR-122) Description: GalNAc-conjugated antagonist targeting miR-122...
BioCentury | Jun 29, 2016
Company News

Regulus shares fall after clinical hold news

...treated with RG-101 (see BioCentury Extra, June 27) . RG-101 is a GalNAc-conjugated antagonist targeting miR-122. BC...
BioCentury | Jun 28, 2016
Top Story

Regulus sinks on clinical hold

...studies of RG-101, all of which have completed dosing. RG-101 is a GalNAc-conjugated antagonist targeting miR-122...
BioCentury | Jun 6, 2016
Company News

GlaxoSmithKline, Regulus deal

...Regulus did not respond in time for publication. RG-101 is a galNAc-conjugated antagonist targeting microRNA-122 (miR-122...
BioCentury | Jun 2, 2016
Translation in Brief

Setting boundaries

...also caused a large drop in levels of the most abundant microRNA in liver, microRNA-122 (miR-122...
...miR-122) , and de-repression of its target genes. Kay told BioCentury his team became convinced miR-122...
...constructs didn't induce toxicity in miR-122-knockout mice, and an AAV vector expressing high levels of miR-122...
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