BioCentury | May 11, 2017
Tools & Techniques

Stemming the tide

...growth in mice compared with an empty vaccine December 2015 MicroRNA-100 (miR-100) Breast cancer Overexpression of miR-100...
BioCentury | Mar 3, 2017
Clinical News

NA-1: Ph III ESCAPE-NA-1 started

...over 90 days Status: Phase III started Milestone: NA Julian Zhu NoNO Inc. Discs large homolog 4 (PSD95) (DLG4) MicroRNA-100...
BioCentury | Jun 30, 2016
Distillery Techniques

Techniques: A 15-microRNA (miRNA) signature to predict survival in patients with colon, pancreatic and stomach cancers

...of a 15-miRNA signature that included microRNA let-7c ( MIRLET7C ; let-7c), microRNA-99a (miR-99a) , miR-100...
BioCentury | Jul 16, 2015
Distillery Therapeutics

Therapeutics: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL); nuclear factor of κ light polypeptide gene enhancer in B cells 1 (NF-κB; NF

...miR-30c or miR-100 could help treat TRAIL-resistant lung cancer. Levels of NF-κB, miR-21, miR-30c and miR-100...
...volume more than the NF-κB inhibitor alone. Next steps include knocking down miR-21, miR-30c and miR-100...
...cells 1 (NF-κB; NFKB1 ; p105 ; p50 ); microRNA-21 (miR-21) ; microRNA-30c (miR-30c) ; microRNA-100 (miR-100)...
BioCentury | Dec 4, 2014
Distillery Therapeutics

Indication: Cardiovascular disease

...regulator of chromatin subfamily a member 5 (SMARCA5; SNF2H); farnesyltransferase CAAX box-b (FNTB); microRNA-99 (miR-99); miR-100...
...MI. In a zebrafish cardiac injury model, regenerating cardiac tissue exhibited lower levels of mir-99, mir-100...
...mice were comparable. In the mouse model of MI, intracardial delivery of oligonucleotides against miR-99, miR-100...
BioCentury | Oct 30, 2014
Distillery Therapeutics

Indication: Cancer

...miR-100 expression could help treat breast cancer. In primary breast tumor samples, low levels of miR-100...
...compared with unaltered miR-100 expression. In mice with human breast cancer xenograft tumors, overexpression of miR-100...
...and metastasis compared with unaltered miR-100 expression. Next steps include identifying a delivery method for miR-100...
BioCentury | Nov 18, 2010
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Liver cancer MicroRNA-100 (miR-100); miRNA-let7a-2 (MIRLET7a2; LET-7a2...
...miRNAs could help guide treatment for liver cancer. Expression profiling in hepatoblastoma tumors identified four miRNAs-miR-100...
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