BioCentury | Jul 13, 2018
Preclinical News

RXR a potential minimal residual disease target in melanoma

...activity of microphthalmia-associated transcription factor (MITF), MITF-high cells, neural crest stem cells or invasive cells with low MITF...
BioCentury | Jun 9, 2016
Translation in Brief

Cell by cell

...exclusive program associated with sensitivity to MEK and BRAF inhibitors and high levels of microphthalmia-associated transcription factor (MITF...
BioCentury | Feb 5, 2015
Distillery Therapeutics

Therapeutics: AXL receptor tyrosine kinase (AXL; UFO); BRAF; MEK; microphthalmia-associated transcription factor (MITF)

...that express low levels of MITF to targeted therapies. In treatment-naive melanoma cell lines, low MITF...
...was associated with increased resistance to BRAF and MEK inhibitors. In melanoma cells with low MITF...
...development to treat various cancers. TARGET/MARKER/PATHWAY: AXL receptor tyrosine kinase (AXL; UFO); BRAF; MEK; microphthalmia-associated transcription factor (MITF...
BioCentury | Dec 19, 2013
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Melanoma BRAF; MEK; microphthalmia-associated transcription factor (MITF); histone...
...BRAF, MEK or MAPK inhibitors. Hits from the screen, which included the melanocyte developmental regulator MITF...
...a drug-resistant melanoma cell line, an HDAC inhibitor plus a BRAF or MEK inhibitor decreased MITF...
BioCentury | Oct 3, 2013
Distillery Techniques

Technology: Assays & screens

...drivers of mutant BRAF-expressing melanoma growth. Sequencing identified insertions in 2 known melanoma drivers, microphthalmia-associated transcription factor (Mitf...
BioCentury | Oct 20, 2011
Distillery Therapeutics

Indication: Cancer

...week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Melanoma Microphthalmia-associated transcription factor (MITF...
...In melanoma samples, greater HIF1 expression was associated with lower expression of the melanoma oncogene MITF...
...In a xenograft mouse model of melanoma, the nonspecific prolyl hydroxylase inhibitor dimethyloxalylglycine, which decreases MITF...
BioCentury | Sep 24, 2009
Distillery Therapeutics

Indication: Cancer

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Melanoma Microphthalmia-associated transcription factor (MITF); TYRO3 protein tyrosine...
BioCentury | Jan 22, 2009
Tools & Techniques

Bead-based kinase profiling

...trials to treat pancreatic cancer, non-small cell lung cancer (NSCLC) and microphthalmia transcription factor ( MITF...
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