BioCentury | Jun 11, 2020
Deals

Cullinan adds first-in-class asset in hot NK cell checkpoint space

...response it triggers. “Tumors use certain enzymes to shave MICA off their surface, and if MICA...
...blocking the site where proteases clip MICA from the cell surface. The result is that MICA...
...B round (see “Founding Investors MPM, F2 Back Cullinan’s Asset-Centric Approach” ). Targets MICA - MHC class I polypeptide-related sequence A...
BioCentury | Dec 27, 2019
Company News

Two-year-old Xyphos gains exit as Astellas scoops up CAR T switch platform

...peptides. MicAbodies are fusion peptides that combine engineered effector domains of the cell surface protein MICA...
...UFO) - AXL receptor tyrosine kinase FLT3 (CD135) - FMS-like tyrosine kinase 3 MICA - MHC class I polypeptide-related sequence A Erin...
BioCentury | Oct 16, 2019
Company News

GammaDelta spins out Adaptate to focus on antibody therapies

...in the circulation. In contrast, γδ T cells respond to stress signals such as MHC class I polypeptide-related sequence A (MICA...
BioCentury | Jul 19, 2019
Product Development

Why GammaDelta would do its Takeda build-to-buy all over again

...time in the circulation. In contrast, γδ T cells respond to stress signals such as MICA...
...Pharmaceutical Co. Ltd. (Tokyo:4502; NYSE:TAK), Tokyo, Japan TC Biopharm Ltd., Holytown, U.K. Targets MICA - MHC class I polypeptide-related sequence A Karen...
BioCentury | Jun 8, 2018
Tools & Techniques

NK cell check-in

...Preclin CanCure LLC CuraB-20 Antibody MICA / MICB Preclin Innate Pharma S.A. (Euronext:IPH) IPH4301 Antibody MICA...
...Rohlff, Oxford BioTherapeutics Among its newer, preclinical programs is IPH4301, a preclinical mAb that blocks MICA...
...2 KIR2DL3 - Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3 MICA - MHC class I polypeptide-related sequence A...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Hello RNA

BioCentury’s analysis of new and emerging targets presented at this year’s AACR meeting reveals a surge in activity in non-coding RNAs, as researchers continue to expand target space. The results also reflect the ongoing high...
BioCentury | Apr 3, 2018
Distillery Therapeutics

Cancer

...INDICATION: Melanoma, colorectal cancer Mouse studies suggest antibodies against the conserved α3 domain of MICA and...
...S.A. has IPH4301, a human mAb against MICA, in preclinical testing for cancer. TARGET/MARKER/PATHWAY: MHC class I polypeptide-related sequence A (MICA...
...doi:10.1126/science.aao0505 CONTACT: Kai W. Wucherpfennig, Dana-Farber Cancer Institute, Boston, Mass. email: kai_wucherpfennig@dfci.harvard.edu Jennie Walters Dana-Farber Cancer Institute MHC class I polypeptide-related sequence A (MICA) MHC...
BioCentury | Mar 30, 2018
Preclinical News

Targeting stress proteins on cells to help treat cancer

...treat cancer by aiding NK cell's antitumor efforts. Many cancers express the stress proteins MHC class I polypeptide-related sequence A (MICA...
...alpha 3 domain of MICA to identify a mAb that bound to the domain. As MICA...
...amount of shed MICA in the melanoma model and decreased tumor growth in tumors expressing MICA...
BioCentury | Oct 5, 2017
Product R&D

Avidly specific

...that combine engineered effector domains of MICA with antibodies that target tumor or viral antigens. MICA...
...convertibleCARs contain a modified version of NKG2D as the CAR, designed to bind the MicAbody MICA...
...growth factor receptor HER2 (EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 MICA - MHC class I polypeptide-related sequence A...
BioCentury | Jun 29, 2017
Product R&D

Drop the MIC

...PROFILE INNOVATION STAGE Product mAbs against soluble MICA and MICB Concept Blocking the activity of MICA...
...MICA and MICB. Animals treated with an anti-CTLA-4 mAb that had low levels of soluble MICA...
...CD247) CTLA-4 (CTLA4; CD152) - Cytotoxic T-lymphocyte associated protein 4 IL-2 - Interleukin-2 MICA - MHC class I polypeptide-related sequence A...
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