BioCentury | Jul 3, 2020
Translation in Brief

Tesla developing RNA therapeutic ‘microfactories’ for CureVac, plus CRISPR-directed RNA epigenetic modifications and Nucleix

...described the tools -- including a catalytically inactivated version of Cas13b fused to the enzyme METTL3...
...EU, where it has CE Mark approval. Targets Cas13b - CRISPR-associated protein 13b METTL3 - methyltransferase like 3...
...14 BioCentury Staff Bladder EpiCheck CureVac AG Broad Institute of MIT and Harvard Nucleix Ltd. CRISPR-associated protein 13b (Cas13b) Methyltransferase like 14 (METTL14) Methyltransferase like 3 (METTL3) Tesla...
BioCentury | Jun 5, 2020
Deals

AstraZeneca adds RNA-modifying targets to oncology pipeline via Accent deal

...has exclusive, global options to license another two programs in discovery. Accent’s lead product targets METTL3...
...Therapeutics Ltd., which has a METTL3 inhibitor; and Gotham Therapeutics Corp., which is targeting the METTL3/METTL14...
...biology, including splicing and translational regulation. Targets ADAR (ADAR1) - Adenosine deaminase RNA-specific METTL3 - Methyltransferase like 3...
BioCentury | Apr 23, 2020
Finance

RNA epigenetic cancer company Accent adds $63M in series B round

...Venture and The Column Group. Accent Therapeutics Inc. CEO Shakti Narayan told BioCentury the company’s METTL3-targeting...
...was the first to demonstrate preclinical proof of concept in the field for its own METTL3...
...Targets ADAR (ADAR1) - Adenosine deaminase RNA-specific METTL3 - Methyltransferase like 3 Stephen Hansen, Associate Editor Accent Therapeutics Inc. Methyltransferase like 3 (METTL3) Adenosine...
BioCentury | Sep 20, 2019
Preclinical News

Storm shows PoC for RNA epigenetic inhibitor as field moves toward clinic

...its METTL3 inhibitor produced the same effects as genetic deletion of the methyltransferase domain of METTL3...
...inhibition of METTL3 increased survival and decreased tumor growth compared with normal METTL3 expression (see “METTL3...
...Methyltransferase like 14; METTL3 - Methyltransferase like 3 Allison Johnson, Senior Writer Storm Therapeutics Ltd. Accent Therapeutics Inc. Gotham Therapeutics Corp. Methyltransferase like 3 (METTL3) RNA...
BioCentury | Jul 19, 2019
Tools & Techniques

A mark up for RNA epigenetics

...in part because it is the most abundant and enzymes that modulate it, such as METTL3...
...cancer pathogenesis, said Storm CSO Oliver Rausch. Accent’s lead program targets METTL3 and Gotham’s the METTL3/METTL14...
...China University of Chicago, Chicago, Ill. Weill Cornell Medicine, New York, N.Y. Targets METTL3 - Methyltransferase like 3...
BioCentury | Feb 28, 2019
Emerging Company Profile

Gotham’s RNA utility belt

...identify RNA epigenetic targets for cancer. Gotham’s targets are also undisclosed but Mueller confirmed that METTL3...
...be among them. In a 2017 Nature Medicine study , Jaffrey’s lab showed depletion of METTL3...
...Storm Therapeutics Ltd., Cambridge, U.K. Weill Cornell Medical College, New York, N.Y. Targets METTL3 - Methyltransferase like 3 Sandi...
BioCentury | Oct 12, 2018
Finance

Versant seizes the RNA moment

...m6A) pathway. In a 2017 Nature Medicine study , Jaffrey and colleagues showed depletion of methyltransferase like 3 (METTL3)...
BioCentury | Oct 3, 2018
Distillery Therapeutics

Cancer

...INDICATION: Lung cancer; cancer Patient sample, cell culture and mouse studies suggest inhibiting the METTL3-EIF3H interaction...
...disrupt the METTL3-EIF3H interaction decreased colony formation compared with expression of wild-type METTL3. In a METTL3-transformed...
...METTL3. Next steps could include developing a small molecule inhibitor of the METTL3-EIF3H interaction. TARGET/MARKER/PATHWAY: Methyltransferase like 3 (METTL3)...
BioCentury | Oct 3, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: September 2018

...cancer Eukaryotic translation initiation factor 3 subunit H (EIF3H) Cell culture studies suggest inhibiting the EIF3H-methyltransferase like 3 (METTL3)...
BioCentury | Sep 20, 2018
Preclinical News

RNA-modifying enzyme loops mRNA to increase oncogene translation

...enzymes for cancer. A 2017 Nature study from the University of Cambridge and Storm linked methyltransferase like 3 (METTL3)...
...studies suggested METTL3 recruits translation factors to the RNA methylation site, the mechanisms by which METTL3...
...of a METTL3 mutant with impaired EIF3H binding decreased cell invasiveness and colony formation. The METTL3...
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