BioCentury | Jun 28, 2019
Preclinical News

June 28 Preclinical Quick Takes: BioNTech targets pancreatitis; plus new targets for HIV and more

...PRMT - Protein arginine methyltransferase Karen Tkach Tuzman, Associate Editor; and Hongjiang Li, Staff Writer Epizyme Inc. GlaxoSmithKline plc Methylthioadenosine phosphorylase (MTAP) GSK3368715 Protein...
BioCentury | May 20, 2019
Distillery Therapeutics

MAT2A identified as a target in solid and liquid cancers

...Phase I testing to treat advanced solid tumors in patients with a homozygous deletion of methylthioadenosine phosphorylase (MTAP)...
BioCentury | Sep 29, 2017
Strategy

Agios’ acceleration

...plans to submit an IND this year for AG-270 , a small molecule inhibitor of methylthioadenosine phosphorylase (MTAP)...
BioCentury | May 6, 2017
Product Development

Finding gems in India

...orthogonal” mechanism. Agios’ cancer metabolism portfolio includes molecules that target isocitrate dehydrogenase (IDH) enzymes and methylthioadenosine phosphorylase (MTAP)...
BioCentury | Mar 24, 2017
Company News

Agios Pharmaceuticals, Celgene deal

...Celgene will pay Agios $8 million after designating a development candidate to treat methylthioadenosine phosphorylase (MTAP)-deleted cancers under...
...Pharmaceuticals Inc. (NASDAQ:AGIO), Cambridge, Mass. Celgene Corp. (NASDAQ:CELG), Summit, N.J. Business: Cancer Alicia Parker Agios Pharmaceuticals Inc. Celgene Corp. Methylthioadenosine phosphorylase (MTAP)...
BioCentury | May 23, 2016
Company News

Agios, Celgene deal

...compound. Celgene still holds options to two of Agios’ cancer metabolism programs, including one for methylthioadenosine phosphorylase (MTAP)-deleted...
BioCentury | May 18, 2016
Top Story

Celgene, Agios form new oncology deal, revise another

...compound. Celgene still holds options to two of Agios' cancer metabolism programs, including one for methylthioadenosine phosphorylase (MTAP)-deleted...
BioCentury | Apr 21, 2016
Distillery Therapeutics

Therapeutics: Methionine adenosyltransferase 2A (MAT2A); protein arginine methyltransferase 5 (PRMT5); RIO kinase 1 (RIOK1); methylthioadenosine phosphorylase (

...adenosyltransferase 2A (MAT2A) ; protein arginine methyltransferase 5 (PRMT5) ; RIO kinase 1 (RIOK1) ; methylthioadenosine phosphorylase (MTAP)...
BioCentury | Mar 3, 2011
Distillery Therapeutics

Indication: Various

...disease (CAD); type 2 diabetes Cyclin dependent kinase inhibitor 2B (CDKN2B; INK4B; MTS2); interferon-a21 (IFNA21); methylthioadenosine phosphorylase (MTAP)...
BioCentury | Feb 24, 2011
Targets & Mechanisms

Inflaming cardiovascular passions

Ever since a 2007 genomewide association study uncovered a region of chromosome 9 as a major player in determining risk for cardiovascular diseases, researchers have struggled to understand how locus 9p21 actually causes disease. Now,...
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