BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

New and emerging targets at AACR 2019 show cancer researchers are gaining granularity on how to manipulate the tumor microenvironment, a top priority goal for the field. The targets point to emerging strategies for modulating...
BioCentury | Jul 21, 2016
Distillery Therapeutics

Therapeutics: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2); MLL-AF9 fusion oncogene

...studies suggest inhibiting MTHFD2 could help treat AML. In human AML cell lines, shRNA targeting MTHFD2...
...formation compared with scrambled shRNA. In an orthotopic xenograft mouse model of AML, shRNA targeting MTHFD2...
...identifying and testing MTHFD2 inhibitors in animal models of AML or AML expressing MLL-AF9. TARGET/MARKER/PATHWAY: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)...
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