BioCentury | Oct 31, 2020
Translation in Brief

A method to collect tumor-specific T cells; plus research from Heidelberg University, Black Diamond, KSQ and SynDevRx

...to treat patients with ER-positive, HER2-negative late-stage breast cancer. The company’s preclinical data included demonstration that the MetAP2...
...hyperglycemia caused by a PI3K/Akt inhibition in healthy mice.TARGETSAKT (AKT1; PKB; PKBA) – Protein kinase B MetAP2Methionine aminopeptidase 2 PARP...
...Therapeutics Inc. SynDevRx Inc. Ubiquitin specific peptidase 1 (USP1) Poly(ADP-ribose) polymerase (PARP) Protein kinase B (AKT) (AKT1) (PKB) (PKBA) Methionine aminopeptidase 2 (MetAP2) Phosphoinositide...
BioCentury | Mar 25, 2020
Finance

March 24 Quick Takes: Apexigen brings series C to $123M; plus Nanjing F&S, FCA and Asieris

...Efung Capital, Lapam Capital and Kaitai Capital. The company’s lead candidate APL-1202, a small molecule MetAP2...
...those statements during the COVID-19 crisis. Targets MetAP2 - Methionine aminopeptidase 2 BioCentury Staff APL-1202 Apexigen Inc. Asieris Pharamaceuticals Co. Ltd. Methionine aminopeptidase 2 (MetAP2) Nanjing...
BioCentury | Sep 5, 2019
Company News

Sept. 5 Company Quick Takes: Zafgen exploring alternatives; plus BridgeBio, Global Blood, Akouos, Mallinckrodt, uBiome

...believes will be insufficient for FDA to lift a clinical hold on its second-generation methionine aminopeptidase 2 (MetAP2...
BioCentury | Jul 24, 2019
Company News

July 24 Company Quick Takes: Samsung's Humira biosimilar gets FDA approval; plus Intra-Cellular, Sage and more

...hold Zafgen Inc. (NASDAQ:ZFGN) said FDA agreed to an animal safety study design for methionine aminopeptidase 2 (MetAP2...
...expects top-line data from the animal study by year end (see "Setback for Another Zafgen MetAP2...
BioCentury | Mar 11, 2019
Clinical News

Setback for another Zafgen MetAP2 inhibitor

...findings appear to be specific to the compound. This is at least the third methionine aminopeptidase 2 (MetAP2...
...Type II diabetes. Zafgen said the agency cited a CV safety risk for the second-generation MetAP2...
...report after market close, was off $0.14 to $4.60 on Monday. Brian Moy, Assistant Editor ZGN-1258 Zafgen Inc. Methionine aminopeptidase 2 (MetAP2...
BioCentury | Jan 18, 2019
Clinical News

No safety signals with Zafgen's ZGN-1061 in second cohort of diabetes trial

...Zafgen Inc. (NASDAQ:ZFGN), Boston, Mass. Product: ZGN-1061 Business: Endocrine/Metabolic Molecular target: Methionine aminopeptidase 2 (MetAP2) Description: Second-generation MetAP2...
...diabetes Endpoint: Change in HbA1c value Status: Additional Phase II data Milestone: NA Hongjiang Li ZGN-1061 Zafgen Inc. Methionine aminopeptidase 2 (MetAP2...
BioCentury | Nov 30, 2018
Clinical News

U.S. setback for Zafgen's diabetes therapy

...II diabetes. Zafgen said the agency cited a CV safety risk for the second-generation methionine aminopeptidase 2 (MetAP2...
...Zafgen has further characterized the molecular and systems biology of MetAP2 and optimized its second-generation MetAP2...
...compounds target MetAP2. Next quarter, Zafgen expects to begin Phase I testing of another second-generation MetAP2...
BioCentury | Nov 26, 2018
Clinical News

U.S. setback for Zafgen's diabetes therapy

...II diabetes. Zafgen said the agency cited a CV safety risk for the second-generation methionine aminopeptidase 2 (MetAP2...
...Zafgen has further characterized the molecular and systems biology of MetAP2 and optimized its second-generation MetAP2...
...compounds target MetAP2. Next quarter, Zafgen expects to begin Phase I testing of another second-generation MetAP2...
BioCentury | Sep 27, 2018
Tools & Techniques

Antibacterial peptide derived from structure of a bacteria's essential protein

A new study described an antibacterial synthetic peptide designed from the structure of a bacteria's own essential protein, suggesting targeting the structural core of these proteins could be a fruitful approach for developing species-specific antibiotics...
BioCentury | Jun 29, 2018
Financial News

Kura, Zafgen price follow-ons

...The company expects to present additional data early next year. ZGN-1061 is a second-generation methionine aminopeptidase 2 (MetAP2...
...Diego, Calif. Zafgen Inc. (NASDAQ:ZFGN), Boston, Mass. Jaime De Leon tipifarnib (zarnestra, R115777) ZGN-1061 Kura Oncology Inc. Zafgen Inc. Farnesyl transferase Methionine aminopeptidase 2 (MetAP2) v-Ha-ras...
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