BioCentury | Oct 9, 2020
Translation in Brief

Philogen immunocytokine for glioma; plus Nordic's radiotherapy, Beth Israel Deaconness, Molecular Partners and Alpine

...T cell co-stimulator ligand (ICOSLG) (B7-H2) (B7RP1) CD28 Inducible T cell co-stimulator (ICOS) CC chemokine receptor 5 (CCR5) (CD195) Melanoma cell adhesion molecule (MCAM) (MUC18) (CD146) Transplant Cancer Graft-versus-host...
BioCentury | Oct 20, 2017
Clinical News

Prothena discontinues development of psoriasis/psoriatic arthritis candidate

...the psoriasis/psoriatic arthritis candidate into mid-stage development. PRX003 is a mAb targeting melanoma cell adhesion molecule (MCAM; MUC18; CD146...
...patients with psoriasis showed that PRX003 led to dose- and time-dependent occupancy and downregulation of CD146...
...Dublin, Ireland Product: PRX003 Business: Autoimmune Molecular target: Melanoma cell adhesion molecule (MCAM; MUC18; CD146) Description: mAb targeting CD146...
BioCentury | Jun 25, 2015
Distillery Therapeutics

Therapeutics: Connective tissue growth factor (CTGF); melanoma cell adhesion molecule (MCAM; MUC18; CD146)

...patellar tendon cells, CTGF selectively induced propagation of cells expressing the tendon stem cell marker MCAM...
...transected patellar tendons, fibrin gel-based delivery of CTGF to the injury site increased numbers of MCAM-positive...
...and other tendon diseases. TARGET/MARKER/PATHWAY: Connective tissue growth factor (CTGF) ; melanoma cell adhesion molecule (MCAM; MUC18 ; CD146...
BioCentury | Jun 15, 2015
Clinical News

PRX003: Phase I started

...Dublin, Ireland Product: PRX003 Business: Autoimmune Molecular target: Melanoma cell adhesion molecule (MCAM) (MUC18) (CD146) Description: mAb targeting melanoma cell adhesion molecule (MCAM; MUC18; CD146...
BioCentury | Aug 27, 2012
Strategy

Another cut at Elan

...for AD and other tauopathies. The newco also has a program targeting melanoma cell adhesion molecule (MCAM; MUC18; CD146...
BioCentury | Aug 20, 2012
Company News

Elan neurology, autoimmune news

...by year end. Neotope will develop therapeutics targeting alpha synuclein (SNCA) , melanoma cell adhesion molecule (MCAM; MUC18; CD146...
BioCentury | Aug 14, 2012
Top Story

Elan to spin out drug discovery

...by year end. Neotope will develop therapeutics targeting alpha synuclein (SNCA) , melanoma cell adhesion molecule (MCAM; MUC18; CD146...
BioCentury | Apr 16, 2012
Product Development

CellSearching the heart

...the case of the MI study, the company used an antibody against melanoma cell adhesion molecule (MCAM; MUC18; CD146...
...is attached to small magnetic particles 150-200 nm in size. The antibodies bind to the CD146...
BioCentury | Mar 11, 2010
Distillery Therapeutics

Indication: Cardiovascular disease

...applicable In vitro and rat studies suggest that a soluble form of melanoma cell adhesion molecule (MCAM; MUC18; CD146...
...MUC18; CD146) could help treat ischemia. In cultured human endothelial progenitor cells (EPCs), recombinant soluble CD146...
...proliferation rate compared with vehicle control. In a rat model of hind limb ischemia, soluble CD146...
BioCentury | May 1, 2008
Distillery Techniques

This Week in Techniques

...cell types. At least five companies have compounds targeting mucin 1 (MUC1) or mucin 18 (MUC18...
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