19:46 , Aug 22, 2019 |  BioCentury  |  Emerging Company Profile

Tscan: Tracking down novel T cell targets

Tscan is screening TCRs against a genome-wide library of antigens to systematically identify novel cancer targets for T cell therapies that avoid off-target toxicities. "Most targets have been discovered in a one-off fashion, notably by...
23:52 , Aug 8, 2019 |  BC Innovations  |  Tools & Techniques

Checkpoint inhibitors are bringing oncolytic viruses back into the spotlight

Early clinical readouts for next-generation oncolytic viruses are hinting at high efficacy when combined with checkpoint inhibitors, and pharmas are off to the races to find the best pairings. After more than two decades of...
04:20 , Dec 21, 2018 |  BC Innovations  |  Product R&D

Cell therapies seek solid ground

To make cell therapies work in solid tumors, drug companies will have to either master combination therapies or figure out how to make their treatments trigger broad immune responses that extend beyond the antigen specificity...
19:52 , Oct 13, 2017 |  BC Week In Review  |  Company News

AbbVie acquires options to Turnstone immunotherapies

AbbVie Inc. (NYSE:ABBV) acquired options to license exclusive, worldwide rights to three oncolytic viral immunotherapies from Turnstone Biologics Inc. (Ottawa, Ontario), including the company’s Ad- MG1-MAGEA3 . By combining oncolytic viruses with cancer vaccines, Turnstone...
22:18 , Oct 10, 2017 |  BC Extra  |  Company News

AbbVie, Turnstone in oncolytic virus deal

AbbVie Inc. (NYSE:ABBV) acquired options to license exclusive, worldwide rights to three oncolytic viral immunotherapies from Turnstone Biologics Inc. (Ottawa, Ontario), including the company’s Ad- MG1-MAGEA3 . By combining oncolytic viruses with cancer vaccines, Turnstone...
00:49 , Sep 9, 2017 |  BioCentury  |  Strategy

Some of the parts

The acquisition of Kite Pharma Inc. by Gilead Sciences Inc. could put the industry-leading CAR T pipeline in the hands of the company best-suited to expand the cell therapies into the as-yet-elusive solid tumor space....
18:03 , Sep 1, 2017 |  BC Week In Review  |  Company News

Gilead grabs Kite for nearly $12B

Gilead Sciences Inc. (NASDAQ:GILD) added a late-stage cancer asset and pivoted toward the chimeric antigen receptor (CAR) T cell therapy space after agreeing to acquire Kite Pharma Inc. (NASDAQ:KITE) at $180 per share in cash,...
16:28 , Aug 18, 2017 |  BC Week In Review  |  Clinical News

MAGEA3 T cell therapy safe, leads to responses in NCI study

In a study published in the Journal of Clinical Oncology , researchers at NIH's NCI and colleagues reported that a major histocompatibility complex (MHC) class II-restricted melanoma-associated antigen A3 (MAGEA3)-targeted T cell receptor (TCR) T...
20:51 , Aug 17, 2017 |  BC Extra  |  Clinical News

MAGEA3 T cell therapy safe, leads to responses in NCI study

In a study published in the Journal of Clinical Oncology , researchers at NIH's NCI and colleagues reported that a melanoma-associated antigen A3 ( MAGEA3 )-targeted T cell receptor (TCR) T cell therapy from Kite...
21:41 , Jul 20, 2017 |  BC Innovations  |  Product R&D

Eureka moment for TCR mimics

In the race to access the wealth of intracellular molecular targets once considered undruggable, Eureka Therapeutics Inc. is pioneering TCR -like antibodies that capitalize on the ability of TCRs to recognize tumor antigens. But the...