BioCentury | Jun 28, 2012
Strategy

Pharma compounds at the crossroads

...to treat COPD, MS, liver fibrosis Asthma, emphysema, bacterial infection Bristol-Myers Squibb BMS-830216 Melanin-concentrating hormone receptor 1 (MCHR1; GPR24...
BioCentury | Apr 9, 2012
Regulation

A longer weight

...than 4,000 high-risk patients in a Phase III program. Albany Molecular is developing melanin-concentrating hormone receptor 1 (MCHR1; GPR24...
...antagonists for obesity. The company has conducted preclinical testing of follow-on molecules to first-generation MCHR1...
BioCentury | Oct 24, 2011
Clinical News

ALB-127158: Development discontinued

...Molecular Research Inc. (NASDAQ:AMRI), Albany, N.Y. Product: ALB-127158(a) Business: Endocrine/Metabolic Molecular target: Melanin-concentrating hormone receptor 1 (MCHR1) (GPR24) Description: Melanin-concentrating hormone receptor 1 (MCHR1...
BioCentury | Jun 20, 2011
Clinical News

ALB-127158: Phase I data

...Molecular Research Inc. (NASDAQ:AMRI), Albany, N.Y. Product: ALB-127158(a) Business: Endocrine Molecular target: Melanin-concentrating hormone receptor 1 (MCHR1) (GPR24) Description: Melanin-concentrating hormone receptor 1 (MCHR1...
BioCentury | Feb 7, 2011
Product Development

Obesity Reset

...wanting to eat," Sargent told BioCentury. Albany Molecular is focused on antagonizing the melanin-concentrating hormone receptor 1 (MCHR1; GPR24...
...that pass through the hypothalamus, and nearly all of these signals go through MCH neurons. "MCHR1...
...Second-generation cannabinoid CB1 receptor (CNR1) antagonist Ph I Albany Molecular Research Inc. (NASDAQ:AMRI) ALB-127158(a) Melanin-concentrating hormone receptor 1 (MCHR1...
BioCentury | Aug 12, 2010
Targets & Mechanisms

The GPCR-cancer connection

Researchers from Roche 's Genentech Inc. unit have identified a host of somatic mutations and gene copy number alterations across human cancers that represent potential targets for the disease. 1 Nineteen of the 112 candidate...
BioCentury | Aug 2, 2010
Clinical News

ALB-127158: Phase I started

...Research Inc. (NASDAQ:AMRI), Albany, N.Y. Product: ALB-127158(a) Business: Endocrine Molecular target: Melanin-concentrating hormone receptor 1 (MCHR1) Description: Melanin-concentrating hormone receptor 1 (MCHR1...
BioCentury | Oct 12, 2009
Company News

Epix deal

...PRX-03140, a serotonin (5-HT4) receptor agonist in Phase II testing for Alzheimer's disease; a melanin concentrating hormone receptor 1 (MCHR1...
BioCentury | Apr 2, 2009
Distillery Techniques

Technology: Computational models

...library of compounds. Researchers used the tool to identify virtual structures for small molecule melanin-concentrating hormone receptor 1 (MCHR1...
...Synthesis and evaluation of the compounds yielded three candidates that were equipotent to a reference MCHR1...
BioCentury | Jul 31, 2008
Distillery Therapeutics

This Week in Therapeutics

...and contact information Autoimmune disease Inflammatory bowel disease (IBD); Crohn's disease Melanin-concentrating hormone (MCH); melanin-concentrating hormone receptor 1 (MCHR1...
...with what was seen in mice that received control antibody (p<0.05). In the same models, MCHR1...
...p<0.05). Also, inflamed mucosa samples from patients with active IBD experienced upregulation of MCH and MCHR1...
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