07:00 , Mar 24, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Drug-responsive transcription factor PDR1 (PDR1); mediator complex subunit 15 (MED15)

Infectious disease INDICATION: Fungal infection Cell culture, moth and mouse studies suggest inhibiting the microbial PDR1-MED15 interaction could help treat multidrug-resistant (MDR) fungal infections, which frequently involve gain-of-function mutations in PDR1. Screening of a small molecule library...