02:10 , Dec 8, 2017 |  BC Innovations  |  Targets & Mechanisms

Epiphenomena at ASH

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...
20:12 , Jun 5, 2017 |  BC Extra  |  Financial News

Dova, Aileron seek NASDAQ listings

Oncology play Aileron Therapeutics Inc. (Cambridge, Mass.) and rare disease company Dova Pharmaceuticals Inc. (Durham, N.C.) each proposed IPOs on NASDAQ. Stapled peptide therapeutic company Aileron filed to raise $69 million in an offering underwritten by...
19:59 , Apr 11, 2017 |  BC Innovations  |  Distillery Techniques

Biomarkers

TECHNOLOGY: SNPs SNPs on five genomic loci could help predict the risk of glioblastoma multiforme (GBM) and SNPs on eight genomic loci could help predict the risk of non-GBM glioma. Genome-wide association studies in 12,496 glioma...
08:00 , Dec 17, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Mdm4 p53 binding protein homolog (MDM4; MDMX)

Cancer INDICATION: Cancer; lymphoma In vitro, patient sample and mouse studies suggest antisense oligonucleotides targeting MDM4 exon 6 could help treat cancer. Human melanoma, ovarian, breast, and other cancer cell lines and melanoma tumor samples from patients...
08:00 , Mar 2, 2015 |  BC Week In Review  |  Clinical News

ALRN-6924: Phase I started

Aileron began a dose-escalation, U.S. Phase I trial to evaluate ALRN-6924 in 100-150 patients. Aileron Therapeutics Inc., Cambridge, Mass.   Product: ALRN-6924   Business: Cancer   Molecular target: Mdm2 p53 binding protein homolog (MDM2) (HDM2); ...
08:00 , Mar 2, 2015 |  BC Week In Review  |  Company News

Georgia State University, Cisen Pharmaceutical deal

Cisen and Georgia State partnered to develop a preclinical compound from the university to treat leukemia in China. The candidate inhibits the dimerization of mdm2 p53 binding protein homolog ( MDM2; HDM2) and...
01:56 , Nov 19, 2013 |  BC Extra  |  Financial News

Aileron raises $30 million series E

Aileron Therapeutics Inc. (Cambridge, Mass.) raised $30 million in a series E round. All of the company's existing investors participated, including Apple Tree Partners; Roche Venture Fund; Novartis Venture Funds; Lilly Ventures; SR One; and...
08:00 , Nov 19, 2012 |  BC Week In Review  |  Clinical News

Aileron, Roche preclinical data

In in vivo and in vitro models of cancer, ATSP-7041 reactivated the p53-dependent pathway, induced p53-dependent apoptosis and inhibited cell proliferation. ATSP-7041 is a selective stapled peptide dual inhibitor of Mdm2 p53 binding...
07:00 , Sep 17, 2012 |  BioCentury  |  Product Development

Excited about cycling

New synthesis and screening technologies and the allure of access to previously undruggable targets are driving an explosion of new company formation and deal-making around macrocycles and constrained peptides. While it remains to be seen whether...
07:00 , Aug 9, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Melanoma Mdm4 p53 binding protein homolog (MDM4; MDMX) Mouse and cell culture studies suggest antagonizing MDM4 could...