13:30 , Dec 5, 2018 |  BC Innovations  |  Distillery Therapeutics

Hepatic

INDICATION: Non-alcoholic steatohepatitis (NASH) Patient sample and mouse studies suggest inhibiting the Notch pathway components HES1, γ secretase, MAML1 and NCSTN could help treat NASH. In NASH patient liver tissue samples, hepatocyte levels of HES1...
07:00 , Apr 28, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Mastermind like transcriptional coactivator 1 (MAML1); Notch 1 (NOTCH1)

Cancer INDICATION: Cancer In vitro, cell and zebrafish studies identified a thiazolidinedione-based MAML1 inhibitor that could help treat NOTCH1-dependent cancers. In silico screening of small molecule libraries and in vitro testing of hits identified a...
08:00 , Nov 19, 2009 |  BC Innovations  |  Cover Story

A top-notch inhibitor

University of California, San Diego researchers have identified a role for Notch, a signaling pathway typically associated with cancer, in an entirely new indication-pulmonary arterial hypertension. 1 In light of a new way to specifically...