23:17 , Mar 27, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Lung cancer; melanoma; skin cancer Patient sample, cell culture and mouse studies suggest inhibiting ERK-5 in macrophages could help treat melanoma and lung cancer. In skin samples from patients with squamous cell carcinoma (SCC)...
18:09 , Aug 29, 2017 |  BC Innovations  |  Distillery Therapeutics

Infectious disease

INDICATION: Fungal infection In vitro and zebrafish studies suggest promoting macrophage vomocytosis by inhibiting ERK-5 could help treat fungal infections. In a mouse macrophage cell line, an ERK-5 inhibitor tool compound or ERK-5 knockdown increased...
17:02 , Aug 24, 2017 |  BC Innovations  |  Translation in Brief

Spit it out

The identification of ERK-5 as a brake on the process of macrophage vomocytosis not only provides new mechanistic insight into the poorly understood phenomenon but could lead to a strategy for preventing dissemination of fungal...
07:00 , May 19, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: MAP kinase 7 (MAPK7; BMK1; ERK-5); mitogen-activated protein kinase kinase kinase 2 (MAP3K2); WNK lysine deficient protein kinase 1 (WNK1; PPP1R16

Cancer INDICATION: Prostate cancer Patient sample, mouse and cell culture studies suggest inhibiting MAPK7 or the MAPK7 pathway components MAP3K2 and WNK1 could help treat prostate adenocarcinoma cancer harboring gain-of-function FOXF1 mutations. In tissue samples...
07:00 , Jun 12, 2014 |  BC Innovations  |  Targets & Mechanisms

Putting SMYD3 on the MAP

Stanford University and GlaxoSmithKline plc researchers have uncovered the mechanism of action of SMYD3 , a histone lysine methyltransferase overexpressed in many lung and pancreatic tumors. 1 The surprise was that SMYD3 acts in the...
07:00 , Sep 30, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Mitogen-activated protein kinase 7 (MAPK7; BMK1; ERK-5) A study in rodents identified a BMK1 inhibitor that could help treat cancer. In a panel of...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

High probability pathways

High probability pathways Pathway Genes in pathway (A) Pathway components [Ranking] (A) [5] Fibroblast growth factor (FGF) signaling MAP2K4; FGFR4; FGFR1; MAPK14; MAPK8; MAPK9; FGFR3; MAP3K6; MAP3K2; MAPK11; PRKCB1; RAF1; PRKCA; PRKCH; MAPK13; AKT3; PRKCE;...