01:33 , Apr 19, 2019 |  BC Innovations  |  Targets & Mechanisms

The next wave in neurodegeneration expands beyond neurons

Working in the background, while amyloid therapies have floundered, has been a group of companies betting that the immune system can do for neurodegeneration what it is has done for oncology. The first wave of...
21:04 , Jan 5, 2017 |  BC Innovations  |  Translation in Brief

Two faces of tau

Contrary to the dogma that β-amyloid triggers Alzheimer’s disease (AD) by inducing phosphorylation of the neuronal protein tau, an Australian team has shown that the process can in fact be protective rather than pathogenic. In...
14:19 , Nov 30, 2016 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Alzheimer’s disease (AD) Patient sample, cell culture and mouse studies suggest promoting MAPK12 expression could help treat AD. In postmortem cortex tissue samples from AD patients, low levels of MAPK12 correlated with disease progression,...
07:00 , Apr 23, 2007 |  BioCentury  |  Tools & Techniques

High probability pathways

High probability pathways Pathway Genes in pathway (A) Pathway components [Ranking] (A) [5] Fibroblast growth factor (FGF) signaling MAP2K4; FGFR4; FGFR1; MAPK14; MAPK8; MAPK9; FGFR3; MAP3K6; MAP3K2; MAPK11; PRKCB1; RAF1; PRKCA; PRKCH; MAPK13; AKT3; PRKCE;...