BioCentury | Oct 15, 2015
Distillery Therapeutics

Therapeutics: Mannosyl (β-1,4-)-glycoprotein β-1,4-N-acetylglucosaminyltransferase (MGAT3)

...Endocrine/metabolic disease INDICATION: Diabetes In vitro and mouse studies identified an MGAT3 inhibitor that could help...
...that inhibited MGAT3-mediated TAG biosynthesis with an IC50 of 205 nM. In mice expressing human MGAT3...
...Next steps could include testing the compound in models of diabetes. TARGET/MARKER/PATHWAY: Mannosyl (β-1,4-)-glycoprotein β-1,4-N-acetylglucosaminyltransferase (MGAT3...
BioCentury | May 7, 2015
Distillery Therapeutics

Therapeutics: Monoacylglycerol O-acyltransferase 2 (MOGAT2; MGAT2)

Endocrine/metabolic disease INDICATION: Endocrine/Metabolic; hypertriglyceridemia Mouse studies suggest inhibiting MOGAT2 could help treat hyperglyceridemia and other metabolic diseases. Optimization of an N-phenylindoline-5-sulfonamide-based MOGAT2 inhibitor (IC50 = 130 nM) resulted in a new lead compound that...
BioCentury | Jul 18, 2013
Distillery Therapeutics

Indication: Neurology

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Multiple sclerosis (MS) Mannosyl (a-1,6-)-glycoprotein b-1,6-N-acetyl-glucosaminyltransferase isozyme B (MGAT5B) Mouse studies suggest inhibiting MGAT5B could help treat MS. In a mouse...
BioCentury | Aug 25, 2011
Distillery Therapeutics

Indication: Endocrine disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes Mannosyl (a-1,3-)-glycoprotein b-1,4-N-acetylglucosaminyltransferase isozyme A (MGAT4A) Mouse studies suggest preventing loss of MGAT4A activity could help treat type 2 diabetes. In mice fed...
BioCentury | Apr 2, 2009
Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Diabetes; obesity Monoacylglycerol O-acyltransferase 2 (MOGAT2; MGAT2) A study in mice suggests that MGAT2 could be antagonized to treat type...
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