BioCentury | Feb 8, 2020
Tools & Techniques

Beyond PROTACs and the proteasome: broadening the TAC toolbox

The idea of sending disease-driving proteins to the cell’s garbage can is only the first act in a field that now centers around targeted degradation. In the sequel, researchers are extending the principle to other...
BioCentury | Oct 16, 2014
Distillery Therapeutics

Indication: Endocrine/metabolic disease

...Licensing status Publication and contact information Endocrine/metabolic disease Mucopolysaccharidosis N-acetylglucosaminidase-a (NAGLU); insulin-like growth factor-2 (IGF-2); mannose-6-phosphate receptor...
BioCentury | Mar 5, 2001
Emerging Company Profile

Novazyme: Getting the translation right

...and neurological disorders. Many lysosomal enzymes are targeted for transport into the lysosome by the mannose-6-phosphate receptor...
...processing of the enzymes is required in order for them to be recognized by the mannose-6-phosphate receptor...
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