07:00 , Apr 4, 2013 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer Glutamic-oxaloacetic transaminase 1 (GOT1); malate dehydrogenase 1 (MDH1); NADP-dependent malic enzyme (ME1) In vitro and mouse studies suggest inhibiting...
07:00 , Apr 4, 2013 |  BC Innovations  |  Targets & Mechanisms

Glutamine metabolism drives PDAC

Researchers at the Dana-Farber Cancer Institute have identified a glutamine metabolism pathway that is activated by oncogenic K-Ras in pancreatic cancers. 1 Moreover, the team found three different enzyme targets within the pathway that could...