07:00 , Jun 16, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Multiple features of the major histocompatibility complex (MHC) locus as risk markers for psoriasis in the Han Chinese population

Biomarkers TECHNOLOGY: Gene profiling SNPs, HLA alleles and amino acids in the MHC locus could help predict risk of psoriasis in the Han Chinese population. Deep sequencing of the MHC locus in a Han Chinese...
08:00 , Mar 10, 2016 |  BC Innovations  |  Tools & Techniques

Ziopharm bets on the HLA-A odds

Ziopharm Oncology Inc. is adding gene editing to its repertoire with a strategy to increase the odds of finding a match for hematopoietic stem cell transplants. While the system is still short of an allogeneic...
08:00 , Nov 6, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Hematology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Transfusion Major histocompatibility complex class I A (HLA-A); HLA-B; HLA-C In vitro and mouse studies suggest transfusion with HLA-A/B/C- platelets generated from induced pluripotent stem...
07:00 , Jul 25, 2013 |  BC Innovations  |  Tools & Techniques

Universal appeal for CARs

Chimeric antigen receptor-expressing T cells have shown dramatic efficacy in treating blood cancers, but so far only autologous, modified T cells can be used, making manufacturing labor intensive and expensive. Now, The University of Texas...
07:00 , Jun 7, 2012 |  BC Innovations  |  Tools & Techniques

HLA in sequence

A group of Australian researchers and an FDA -led team have independently identified a mechanism behind human leukocyte antigen allele-mediated autoimmune reactions to certain drugs. 1,2 The findings could expand the use of human leukocyte...
07:00 , Sep 29, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Markers

Approach Summary Licensing status Publication and contact information Markers Markers to predict non-responders to interferon-a and ribavirin treatment for HCV A human genetic study suggests genotyping for IL-28B (IL28B; IFNL3) and major histocompatibility complex class...
07:00 , Oct 29, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Autoimmune disease Autoimmune disease; Crohn's disease; multiple sclerosis (MS); myasthenia gravis; rheumatoid arthritis (RA); selective IgA deficiency; systemic lupus erythematosus (SLE); ulcerative colitis (UC) Major...
07:00 , Apr 17, 2008 |  BC Innovations  |  Distillery Techniques

This Week in Techniques

This week in techniques Approach Summary Licensing status Publication and contact information Computational interpretation of whole-genome association (WGA) WGAViewer, a set of Java software tools, may be helpful for interpreting genome-wide association studies and could...