BC Innovations | Jun 7, 2012
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Specific and noncovalent binding of small molecule therapeutics to human leukocyte antigen (HLA) polymorphisms alters peptide antigen presentation In vitro studies...
BC Innovations | Jun 7, 2012
Tools & Techniques

HLA in sequence

A group of Australian researchers and an FDA -led team have independently identified a mechanism behind human leukocyte antigen allele-mediated autoimmune reactions to certain drugs. 1,2 The findings could expand the use of human leukocyte...
BC Week In Review | Jan 2, 2012
Company News

Roche sales and marketing update

Roche launched the Roche HLA-B*5701 Screening Test in Europe to identify patients with the HLA-B*5701 allele, which is associated with a higher risk for hypersensitivity to HIV drug abacavir. The test runs on the Cobas...
BC Extra | Oct 1, 2010
Clinical News

Adverse event consortium begins second phase

The International Serious Adverse Events Consortium (SAEC) began the second phase of ongoing research to identify genetic markers that could predict which patients are at risk of rare drug-related adverse events. Goals for the second...
BioCentury | Aug 16, 2010

PBMs become companions

Pharmacy benefit managers Medco Health Solutions Inc. and CVS Caremark Corp. are expanding into the management of pharmacogenomic testing in an effort to save their clients money and improve clinical outcomes. Their efforts extend beyond...
BC Week In Review | May 31, 2010
Company News

Medco Health Solutions Inc. sales and marketing update

Pharmacy benefit manager Medco's Precision Health Solutions business unit will launch a suite of pharmacogenetic services in July. The unit will offer a CYP2C19 allele test for cardiovascular drug Plavix clopidogrel; a test to identify...
BC Extra | Jun 3, 2009
Clinical News

Consortium publishes liver tox markers

FDA and the International Serious Adverse Events Consortium (SAEC) published in Nature Genetics the results of a genomewide association study that showed patients carrying at least one copy of the HLA-B 5701 allele were 80-100...
BC Week In Review | Mar 9, 2009
Clinical News

Ziagen abacavir regulatory update

FDA cautioned healthcare professionals against using skin patch testing to immunologically confirm suspected cases of hypersensitivity reactions in patients treated with abacavir. The agency said data from several research reports suggest that testing may miss...
BC Innovations | Oct 23, 2008
Tools & Techniques

GSK Gets its Potpourri

GlaxoSmithKline plc has rolled out a database of human genetic variation representing the most comprehensive geographical and ethnic sampling effort to date. The project, termed the Population Reference Sample, could help efforts to predict genetically...
BC Week In Review | Aug 25, 2008
Company News

Qiagen sales and marketing update

Qiagen launched its HLA-B*5701 Olerup SSP-Kit in the EU to type the HLA-B*5701 allele. The PCR-based assay has CE Mark approval in Europe and is available in the U.S. for research use. In July, FDA...
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