BC Innovations | Jun 16, 2016
Distillery Techniques

Techniques: Multiple features of the major histocompatibility complex (MHC) locus as risk markers for psoriasis in the Han Chinese population

Biomarkers TECHNOLOGY: Gene profiling SNPs, HLA alleles and amino acids in the MHC locus could help predict risk of psoriasis in the Han Chinese population. Deep sequencing of the MHC locus in a Han Chinese...
BC Innovations | Mar 10, 2016
Tools & Techniques

Ziopharm bets on the HLA-A odds

Ziopharm Oncology Inc. is adding gene editing to its repertoire with a strategy to increase the odds of finding a match for hematopoietic stem cell transplants. While the system is still short of an allogeneic...
BC Innovations | Nov 6, 2014
Distillery Therapeutics

Indication: Hematology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Hematology Transfusion Major histocompatibility complex class I A (HLA-A); HLA-B; HLA-C In vitro and mouse studies suggest transfusion with HLA-A/B/C- platelets generated from induced pluripotent stem...
BC Innovations | Jul 25, 2013
Tools & Techniques

Universal appeal for CARs

Chimeric antigen receptor-expressing T cells have shown dramatic efficacy in treating blood cancers, but so far only autologous, modified T cells can be used, making manufacturing labor intensive and expensive. Now, The University of Texas...
BC Innovations | Jun 7, 2012
Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Specific and noncovalent binding of small molecule therapeutics to human leukocyte antigen (HLA) polymorphisms alters peptide antigen presentation In vitro studies...
BC Innovations | Jun 7, 2012
Tools & Techniques

HLA in sequence

A group of Australian researchers and an FDA -led team have independently identified a mechanism behind human leukocyte antigen allele-mediated autoimmune reactions to certain drugs. 1,2 The findings could expand the use of human leukocyte...
BC Week In Review | Jan 2, 2012
Company News

Roche sales and marketing update

Roche launched the Roche HLA-B*5701 Screening Test in Europe to identify patients with the HLA-B*5701 allele, which is associated with a higher risk for hypersensitivity to HIV drug abacavir. The test runs on the Cobas...
BC Week In Review | Nov 1, 2010
Company News

Linkage Biosciences sales and marketing update

Linkage Biosciences launched three human leukocyte antigen (HLA) typing tests in the U.S. The intermediate resolution HLA-DQ test types the major histocompatibility complex class II DQ locus alpha 1 ( HLA-DQA1 ) and major histocompatibility complex class...
BC Extra | Oct 1, 2010
Clinical News

Adverse event consortium begins second phase

The International Serious Adverse Events Consortium (SAEC) began the second phase of ongoing research to identify genetic markers that could predict which patients are at risk of rare drug-related adverse events. Goals for the second...
BioCentury | Aug 16, 2010

PBMs become companions

Pharmacy benefit managers Medco Health Solutions Inc. and CVS Caremark Corp. are expanding into the management of pharmacogenomic testing in an effort to save their clients money and improve clinical outcomes. Their efforts extend beyond...
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