BioCentury | Oct 22, 2020
Product Development

CRISPR’s data hint allogeneic CAR Ts may have the efficacy and safety issues of autologous therapies

...β-2 microglobulinBCMA (TNFRSF17; CD269) – Tumor necrosis factor (TNF) receptor superfamily member 17CD70 – CD27LMHCI – Major histocompatibility complex...
BioCentury | Oct 9, 2020
Emerging Company Profile

A2: targeting lost genetic material to distinguish tumors from normal cells

...Casdin Capital, Euclidean Capital, UC Investments, and Hartford HealthCare EndowmentCEO: Scott ForakerPatents: None issuedTARGETSMHCMajor histocompatibility complex Danielle...
BioCentury | Sep 26, 2020
Product Development

Merck’s myeloid data add support for the emerging target class

...necrosis factor receptor superfamily member 9HLA-G – Major histocompatibility complex...
BioCentury | Aug 6, 2020
Emerging Company Profile

Off-the-shelf cell therapy pioneers, Versant launch Matterhorn to tackle broad range of cancers

...HLALS) - Major histocompatibility complex, class I-related TCR - T cell receptor Danielle Golovin, Staff Writer Versant Ventures Ervaxx Ltd. Cardiff University Major histocompatibility complex...
BioCentury | Jul 21, 2020
Deals

With deal for Tizona, Gilead places latest bet on cancer immunosuppression

...from Tizona. Targets HLA-G - Major histocompatibility complex class I G Paul Bonanos, Associate Editor Tizona Therapeutics Inc. Gilead Sciences Inc. Major histocompatibility complex...
BioCentury | Jun 11, 2020
Deals

Cullinan adds first-in-class asset in hot NK cell checkpoint space

...B round (see “Founding Investors MPM, F2 Back Cullinan’s Asset-Centric Approach” ). Targets MICA - MHC...
...Killer cell lectin-like receptor subfamily K member 1 Lauren Martz, Senior Editor Cullinan Oncology LLC PDI Therapeutics Inc. Avalon Ventures MHC...
BioCentury | May 21, 2020
Emerging Company Profile

Repertoire bets on both sides of the TCR-antigen coin

...trio of platforms to pinpoint interactions between disease-relevant T cells and antigenic peptides presented on MHC...
...a screening system based on cells that express hybrid cell surface receptors in which extracellular peptide-MHC...
...Fund CEO: John Cox Targets MHC - Major histocompatibility complex MHCI - Major histocompatibility complex class I MHCII - Major histocompatibility complex...
BioCentury | May 9, 2020
Product Development

A guide to COVID-19 vaccine modalities in the clinic

...serine 2 Danielle Kopke, Staff Writer Transmembrane protease serine 2 (TMPRSS2) SARS-CoV-2 spike protein (SARS-CoV-2 S) Angiotensin-converting enzyme 2 (ACE2) Major histocompatibility complex (MHC) Human...
BioCentury | Feb 14, 2020
Targets & Mechanisms

Entrepreneur watch: Iwasaki targets the lymphatic system to clear brain tumors

...brain and peripheral nerve tissues to control viral infections. Her group found intranasal delivery of MHC...
...blood-brain barrier permeability to albumin sevenfold, and giving a checkpoint inhibitor in combination with an MHC...
BioCentury | Feb 6, 2020
Product Development

Early signs CAR NKs could compete with CAR Ts in heme cancers

...CD16 - Fcγ receptor III (CD16; FCGR3) IL-2 - Interleukin-2 IL-15 - Interleukin-15 MHC - Major histocompatibility complex...
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