19:21 , May 6, 2019 |  BC Innovations  |  Distillery Therapeutics

Butyrate for C. difficile-induced colitis

DISEASE CATEGORY: Gastrointestinal INDICATION: Colitis Cell culture and mouse studies suggest butyrate or promotion of its synthesis could help treat Clostridium difficile -induced colitis. In human colon epithelium cells treated with supernatants from C. difficile...
19:35 , Apr 10, 2019 |  BC Innovations  |  Distillery Therapeutics

Imidazopyrimidine-based inhibitor of Leishmania proteasome identified to treat visceral leishmaniasis

DISEASE CATEGORY: Infectious disease INDICATION: Leishmaniasis Cell culture, in vitro , mouse, rat and dog studies identified an imidazopyrimidine-based inhibitor of Leishmania proteasome that could help treat visceral leishmaniasis. Chemical synthesis and screening in L....
21:56 , Feb 22, 2019 |  BioCentury  |  Politics, Policy & Law

Azar’s IPI: socialist or capitalist?

The Trump administration’s plan for an international reference pricing scheme for Medicare Part B drugs has provoked vituperative opposition from BIO, PhRMA and their allies who have branded it as an attempt to impose socialism....
03:20 , Feb 16, 2019 |  BioCentury  |  Product Development

ADCs’ inflection point

Industry is writing a new rule book for antibody-drug conjugates that could take the modality beyond the one-size-fits-all approach that has limited its success. By 2Q20, late-stage data from at least four ADCs testing new...
23:46 , Feb 12, 2019 |  BC Extra  |  Politics & Policy

Rubio report outlines Chinese threat to U.S. biotech industry

Biotech opportunities for foreign companies doing business in China may be short-lived as the country builds its domestic biosimilars industry, according to a report released Tuesday by Sen. Marco Rubio (R-Fla.). The report , "Made...
22:44 , Jan 7, 2019 |  BC Extra  |  Politics & Policy

Bipartisan bill to streamline U.S. response to foreign theft of IP may hasten clarity on biotech impact

As the biopharma industry awaits guidance from the government on the scope and potential impact of proposed technology export controls, a new congressional bill could help speed the process. Members of the Senate Select Committee...
18:30 , Nov 30, 2018 |  BC Week In Review  |  Financial News

Inflazome to bring inflammasome inhibitors to clinic with €40M series B

Inflazome Ltd. (Dublin, Ireland) raised €40 million ($45.7 million) in a series B round on Nov. 19, giving it the funds to take several of its inflammasome inhibitors to the clinic next year, including a...
20:11 , Nov 26, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Adenocarcinoma; brain cancer; lung cancer; neuroendocrine tumors Cell culture studies identified a nicotonic acetylcholine receptor α7 (CHRNA7) antagonist that could help treat glioblastoma, lung adenocarcinoma and neuroblastoma. Chemical synthesis and cell-based testing of structural...
20:22 , Nov 19, 2018 |  BC Extra  |  Financial News

Inflazome to bring inflammasome inhibitors to clinic with €40M series B

Inflazome Ltd. (Dublin, Ireland) raised €40 million ($45.7 million) in a series B round Monday, giving it the funds to take several of its inflammasome inhibitors to the clinic next year, including a Parkinson's disease...
18:39 , Oct 18, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Seizures In silico , cell culture and mouse studies identified a GABRB2/GABRB3 positive allosteric modulator (PAM) that could help treat seizures. In silico screening of a small molecule library for structural similarity to a...