16:13 , Aug 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Pain Mouse and rat studies suggest inhibiting PANX1 or its activator P2RX7 in spinal microglia, or an antibody-drug conjugate (ADC) targeting the microglia, could help treat joint pain. In spinal cord samples from a...
16:49 , Feb 13, 2018 |  BC Innovations  |  Distillery Therapeutics

Inflammation; infectious disease

INDICATION: Inflammatory disease; sepsis...
16:00 , Jun 7, 2017 |  BC Innovations  |  Distillery Therapeutics

Cardiovascular

INDICATION: Thrombosis Mouse studies suggest inhibiting the MAC-1 - GP1BA interaction could help treat thrombosis. In a mouse model of microvascular thrombosis, knockout of MAC-1 decreased platelet accumulation in arterioles compared with normal MAC-1 expression....
21:45 , May 12, 2017 |  BioCentury  |  Strategy

Vertical vision

Shire plc ’s deal with Parion Sciences Inc. is a step toward building vertically in ophthalmics, much like it has done in hereditary angioedema and hemophilia. On May 1, Shire gained exclusive, worldwide rights to...
18:50 , May 1, 2017 |  BC Extra  |  Company News

Shire, Parion in deal for ENaC inhibitor for dry eye

Parion Sciences Inc. (Durham, N.C.) granted Shire plc (LSE:SHP; NASDAQ:SHPG) exclusive, worldwide rights to P-321 ophthalmic solution , an epithelial sodium channel (ENaC) inhibitor in development to treat dry eye disease. Parion received $20 million...
14:57 , Mar 8, 2017 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Breast cancer Zebrafish studies suggest inhibiting TGFβ1 or LFA-1 could help treat metastatic breast cancer. In patient samples, levels of TGFβ1 were higher in primary tumors than in surrounding normal tissue. In two xenograft...
17:31 , Jan 25, 2017 |  BC Innovations  |  Distillery Therapeutics

Renal

INDICATION: Renal Monkey studies suggest inhibiting MAC-1 could help treat chronic kidney disease (CKD) associated with acute kidney injury (AKI). In a monkey model of AKI-induced CKD, a mAb inhibiting the CR3 portion of MAC-1...
07:00 , Sep 5, 2016 |  BC Week In Review  |  Company News

Shire sales and marketing update

Shire launched Xiidra lifitegrast in the U.S. to treat signs and symptoms of dry eye disease in adults. The wholesale acquisition cost (WAC) of a 60-drop container is $426.73. Patients receive one drop of the...
07:00 , Jul 18, 2016 |  BC Week In Review  |  Clinical News

Xiidra lifitegrast regulatory update

FDA approved an NDA from Shire for Xiidra lifitegrast to treat signs and symptoms of dry eye disease in adults. Shire plans to launch the product this quarter. Xiidra is an eye drop formulation of...
01:01 , Jul 12, 2016 |  BC Extra  |  Company News

FDA approves Shire's Xiidra

Shire plc (LSE:SHP; NASDAQ:SHPG) said FDA approved Xiidra lifitegrast ( SHP606 ) to treat signs and symptoms of dry eye disease in adults. The company expects to launch Xiidra this quarter. Shire obtained Xiidra via...