BioCentury | Oct 25, 2019
Tools & Techniques

NASH: how non-invasive biomarkers promise to displace biopsies

...ASK1 (MAP3K5) - Apoptosis signal-regulating kinase 1 FXR (NR1H4) - Farnesoid X receptor LOXL2 - Lysyl oxidase-like...
BioCentury | Sep 5, 2019
Financial News

Sept. 5 Financial Quick Takes: Zealand raises cash as it readies NDA; plus Bellus, Aerie, LNC, Veralox and Sigrid

...sugar in people newly diagnosed with and at risk for Type II diabetes. Targets: ALOX12 (12-LOX...
BioCentury | Dec 15, 2018
Product Development

O’Day’s expansive task at Gilead

...Preclin Autoimmune disease 2010 Up to $120M Ph II Arresto BioSciences Inc. AB0024, mAb against lysyl oxidase-like...
BioCentury | Apr 13, 2018
Tools & Techniques

Personalizing prevention

PlaqueTec Ltd. is working to bring personalized medicine to the cardiovascular space with a device that samples local concentrations of molecules near atherosclerotic plaques. By using these samples to identify prognostic and predictive biomarkers, the...
BioCentury | Jan 5, 2018
Company News

Roche acquiring Ignyta for $1.7B

...with Bayer AG (Xetra:BAYN) to develop and commercialize larotrectinib and a second selective Trk inhibitor. Lox...
BioCentury | Jan 2, 2018
Distillery Therapeutics

Hepatic

...identifying and testing ALOX12 inhibitors in models of ischemia/reperfusion-induced liver injury. TARGET/MARKER/PATHWAY: Arachidonate 12-lipoxygenase (ALOX12; 12-LOX...
...Hongliang Li, Renmin Hospital of Wuhan University, Wuhan, China email: lihl@whu.edu.cn Hongjiang Li Wuhan University Arachidonate 12-lipoxygenase (ALOX12) (12-LOX...
BioCentury | Dec 22, 2017
Company News

Roche acquiring Ignyta for $1.7B

...with Bayer AG (Xetra:BAYN) to develop and commercialize larotrectinib and a second selective Trk inhibitor. Lox...
BioCentury | Aug 29, 2017
Distillery Therapeutics

Cancer

...Pharmaxis Ltd. has the LOXL2 inhibitor PXS-5033A in preclinical testing to treat liver fibrosis. TARGET/MARKER/PATHWAY: Lysyl oxidase-like...
...doi:10.1158/0008-5472.CAN-16-3152 CONTACT: Amparo Cano, Autonomous University of Madrid, Madrid, Spain email: acano@iib.uam.es Alicia Parker Autonomous University of Madrid Lysyl oxidase-like...
BioCentury | Aug 17, 2017
Finance

Built to purpose

...HER2 (EGFR2; ErbB2; neu) - Epidermal growth factor receptor 2 KRAS - K-Ras LOXL2 - Lysyl oxidase-like...
BioCentury | May 3, 2017
Distillery Therapeutics

Cancer

...could help treat breast cancer. In in vitro LOX activity assays, a thiophenylmethanamine-based compound inhibited LOX...
...with vehicle. Next steps include clinical testing of the compound in breast cancer patients. TARGET/MARKER/PATHWAY: Lysyl oxidase (LOX)...
...Richard Marais, University of Manchester, Manchester, U.K. email: richard.marais@cruk.manchester.ac.uk Hongjiang Li The Institute of Cancer Research University of Manchester Lysyl oxidase (LOX)...
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