BC Innovations | Jun 4, 2019
Distillery Therapeutics

RELMα and RETN for Gram-positive and Gram-negative bacterial infections

DISEASE CATEGORY: Infectious disease INDICATION: Gram-positive bacterial infection; Gram-negative bacterial infection; Pseudomonas; Streptococcus Bacterial culture studies suggest RELMα and RETN could help treat Gram-positive and other bacterial infections. In cultures of Gram-positive Streptococcus pyogenes and...
BC Extra | Feb 7, 2019
Preclinical News

Novo, MIT develop oral biologic delivery device

A team including Massachusetts Institute of Technology and Novo Nordisk A/S (CSE:NOVO B; NYSE:NVO) scientists have developed an ingestible pill-sized device that can deliver drugs, including insulin, directly to the gastric mucosa. The device --...
BC Innovations | Jan 11, 2017
Distillery Techniques

Drug platforms

TECHNOLOGY: Structural analyses Crystallographic studies of CCR9 and CCR2 bound to antagonists could aid the design of allosteric inhibitors of chemokine receptors. Structural analysis of a 315-residue region of a mutant, thermostabilized version of CCR9...
BC Innovations | Apr 7, 2016
Translation in Brief

Knowing when to fold

A team from the Flanders Institute for Biotechnology (VIB) has linked two genes involved in the unfolded protein stress response to the fragility of pancreatic β cells involved in both Type I and Type II...
BC Innovations | Apr 7, 2016
Distillery Techniques

Disease models

TECHNOLOGY: Transgenics and knockoutsGLIS3-knockout mice transgenically expressing chicken LYZ in pancreatic β cells could be useful for screening therapies to treat Type I and Type II diabetes. In mice, systemic heterozygous knockout of GLIS3 and...
BC Innovations | Apr 23, 2015
Distillery Techniques

Techniques: Antibody-based protease inhibitors

Drug platforms TECHNOLOGY: Antibody scaffolds In vitro studies suggest insertion of disulfide-bridged peptide inhibitors of serine proteases into antibody CDR3 domains could generate protease inhibitors with high target affinity and specificity. The CDR3H loop of...
BC Innovations | Jul 12, 2012
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Gram-negative bacterial infection Pesticin receptor protein (FyuA) In vitro studies identified a modified variant of pesticin that could help treat Gram-negative bacterial infections. Pesticin...
BC Innovations | May 3, 2012
Tools & Techniques

Evolution not revolution

An international team has engineered enzymes capable of replicating nucleic acid polymers that are made of non-natural nucleotides. 1 Despite general media reports that the findings are a breakthrough on the way to artificial life,...
BC Innovations | Apr 8, 2010
Distillery Techniques

Technology: Drug delivery

Approach Summary Licensing status Publication and contact information Drug delivery Synthetic skin-permeable proteins made from low-molecular weight protamine (LMWP) peptide conjugated to antigenic proteins Studies in mice suggest that skin-permeable proteins could be useful for...
BC Innovations | Sep 25, 2008
Distillery Techniques

This Week in Techniques

This week in techniques Approach Summary Licensing status Publication and contact information Tunable membrane protein overexpression in Escherichia coli An engineered E. coli. strain provides a tunable membrane protein overexpression system for controlling protein synthesis...
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