22:50 , Apr 10, 2018 |  BC Innovations  |  Distillery Therapeutics

Cancer

INDICATION: Retinoblastoma Mouse studies suggest inhibiting KDM5A could help treat RB1-deficient retinoblastoma. In an RB1-haploinsufficient mouse model of retinoblastoma, systemic knockout of KDM5A decreased tumor growth and increased survival compared with normal KDM5A expression. Next steps...
07:00 , Sep 1, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Crystal structures of lysine-specific demethylase 5A (KDM5A)-inhibitor complexes to guide structure-based drug design

Drug platforms TECHNOLOGY: Structural analyses Crystallographic analyses of KDM5A bound to tool compound inhibitors could help guide the development of selective and potent KDM5A inhibitors to treat breast cancer. High-resolution structural analyses of co-crystals of a 588-residue...