07:00 , Apr 11, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Bacteriophage T4 co-delivery of DNA and proteins for prime-boost vaccines Cell culture and mouse studies suggest co-delivery of DNA and proteins...
08:00 , Jan 31, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Sortase-mediated modification of a targeted mAb to improve antigen delivery and presentation Sortase-mediated modification of therapeutic mAbs could be useful for developing vaccines and therapeutics...
07:00 , Apr 28, 2011 |  BC Innovations  |  Tools & Techniques

Next-generation dendritic cell vaccines

Vaccine makers have known for years that delivering immunogenic antigens to dendritic cells can elicit the strong T cell-based immune response that is key to combating viral and bacterial infections and cancer. But complexities of...
07:00 , Oct 7, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Autoimmune disease

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Autoimmune disease Multiple sclerosis (MS) Lymphocyte antigen 75 (LY75; DEC-205); proteolipid protein 1 (PLP1) A study in mice suggests that DEC-205-targeted...
07:00 , Aug 19, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease HIV/AIDS Lymphocyte antigen 75 (LY75; DEC205); HIV p24 A study in mice identified DEC205-targeting mAbs that could help deliver a protein-based vaccine to...
07:00 , Mar 27, 2008 |  BC Innovations  |  Cover Story

Antigens by Special Delivery

DNA vaccines often require high and repeated dosing of antigen, which suggests suboptimal priming of the immune system and results in weak immunogenicity. 1 Separate papers in...