21:48 , Apr 6, 2017 |  BC Innovations  |  Translation in Brief

Undercutting suppression

As the options for combining checkpoint inhibitors with other anticancer agents continue to mount, a new strategy to couple checkpoint blockade with depletion of myeloid-derived suppressor cells (MDSCs) could extend the activity of PD-1 and...
07:00 , Sep 15, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Macrophage receptor with collagenous structure (MARCO; SCARA2); lymphocyte antigen 6 complex locus G (Ly6g; Gr1)

Cancer INDICATION: Chronic lymphocytic leukemia (CLL) Studies in mice suggest depleting macrophages and neutrophils could help treat CLL. In an adoptive transfer mouse model of CLL, macrophage depletion decreased splenic tumor load compared with no...
07:00 , Sep 25, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer CXC chemokine receptor 2 (CXCR2; IL8RB); lymphocyte antigen 6 complex locus G (LY6G; GR1) Mouse and cell culture studies suggest blocking recruitment of GR1+...
07:00 , Aug 9, 2012 |  BC Innovations  |  Targets & Mechanisms

CXCR2 antagonists in breast cancer

A team at the Memorial Sloan-Kettering Cancer Center has shown that CXC chemokine receptor 2 antagonists sensitized tumors to chemotherapy in mouse models of metastatic breast cancer. 1 The team is working on additional preclinical...
07:00 , Jul 22, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Immunosuppressive innate immune cells for heart transplant A study in mice suggests that transplantation of monocytes could help increase graft tolerance. In mice with low...
07:00 , Jul 22, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Assays & screens

Approach Summary Licensing status Publication and contact information Assays & screens Solution capture and high throughput DNA sequencing for the detection of cancer mutations Solution capture and high throughput sequencing of patient DNA samples could...
08:00 , Feb 7, 2008 |  BC Innovations  |  Targets & Mechanisms

Unraveling Bv8

Researchers at Genentech Inc. have added three big pieces to the puzzle of how prokineticin 2 ( PROK2 ; Bv8 ), a cytokine secreted by myeloid cells in the bone marrow, regulates tumor-related angiogenesis. The...