BioCentury | May 13, 2020
Product Development

Arvinas unveils first efficacy signal for targeted protein degradation, points to opportunity in resistant cancers

...AR-V7 - Androgen receptor splice variant 7 CYP17 (CYP17A) - Cytochrome P450 17 alpha-hydroxylase/C17, 20 lyase...
BioCentury | Apr 4, 2020

Investors are seeking only one thing: a sign the pandemic tide is shifting

...Intelligence Senior Editor Lauren Martz contributed reporting to this story. Targets ACLY - ATP citrate lyase...
BioCentury | Feb 22, 2020
Product Development

Esperion enters crowded LDL-lowering market with FDA approval Feb. 26. Bempedoic acid blocks cholesterol synthesis in the liver by inhibiting ATP citrate lyase...
...through profitability. The company lost $6.59 (10%) to $61.76 Friday. Targets ACLY - ATP citrate lyase...
BioCentury | Jun 5, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: May 2019

...SMU1 DNA replication regulator and spliceosomal factor (SMU1) Renal Diabetic nephropathy; renal failure Bacterial tyrosine phenol-lyase...
BioCentury | May 20, 2019
Distillery Techniques

RB1 alterations predict survival in mCRPC patients treated with Zytiga or Xtandi

...plc, AstraZeneca plc and Johnson & Johnson market Zytiga, a cytochrome P450 17 α-hydroxylase/C17, 20 lyase...
BioCentury | May 6, 2019
Company News

May 6 Company Quick Takes: Esperion, BioMarin, WuXi AppTec, Axsome, Harbour BioMed/CTTQ, GW, Adynxx patients ages 16 and older with phenylketonuria. FDA approved the pegylated recombinant phenylalanine ammonia lyase...
BioCentury | May 6, 2019
Distillery Therapeutics

Inhibiting bacterial tpl for diabetic nephropathy

...other inhibitors of tpl in models of diabetic nephropathy and renal failure. TARGET/MARKER/PATHWAY: Bacterial tyrosine phenol-lyase...
...23, 2019 doi:10.1038/s41467-019-09735-4 CONTACT: Takaaki Abe, Tohoku University, Sendai, Japan email: Hongjiang Li Tohoku University Bacterial tyrosine phenol-lyase...
BioCentury | Apr 4, 2019
Preclinical News

Nimbus exposes complete ACLY structure, discovers allosteric inhibitory sites

...ATP citrate lyase; AMPK - AMP-activated protein kinase Sandi Wong, Staff Writer Columbia University Nimbus Therapeutics LLC ATP citrate lyase...
BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...Lawrence, Kan. University of Pittsburgh, Pittsburgh, Pa. Targets 2-HG - 2-hydroxyglutarate ACLY - ATP citrate lyase...
BioCentury | Mar 8, 2019
Company News

CHMP recommendations include Ondexxya, Waylivra

...treat patients ages 16 and older with phenylketonuria. FDA approved the pegylated recombinant phenylalanine ammonia lyase...
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