BioCentury | Aug 22, 2020
Translation in Brief

IPD’s synthetic bio unlocks target combos for cell therapy; plus Merck’s oral STING agonist, Surrozen’s regenerative therapy and more

Synthetic switches aim T cells at cells expressing antigen combos David Baker’s team at University of Washington’s Institute for Protein Design published a study in Science showing its synthetic protein switches can direct T cells...
BioCentury | Oct 11, 2018
Financial News

Cancer company Rgenix raises $40M series C

...Ono Pharmaceutical Co. Ltd. (Tokyo:4528). RGX-104 is a small molecule agonist of liver X receptor β (NR1H2; LXR-b...
...Rgenix Inc., New York, N.Y. Jaime De Leon RGX-104 RGX-202 Novo Holdings A/S Rgenix Inc. WuXi AppTec Co. Ltd. Liver X receptor beta (NR1H2) (LXR-b...
BioCentury | Jan 9, 2018
Distillery Therapeutics

Autoimmune disease

...of cholesterol efflux with an LXR agonist tool compound or 2-hydroxypropyl-β-cyclodextrin (HPBCD) -- which promotes LXR...
...VTP-38543, liver X receptor β (NR1H2; LXRβ) agonist, to treat atopic dermatitis. Ralexar Therapeutics Inc. has the LXR...
...RGX-104, a small molecule NR1H2 agonist, in Phase I testing for cancer. TARGET/MARKER/PATHWAY: Cholesterol; liver X receptor (LXR...
BioCentury | Jan 4, 2018
Preclinical News

Cholesterol efflux in phagocytes may promote remyelination

...such as apolipoprotein E (APOE), were lower. Treatment of the old mice with a liver X receptor (LXR...
...to validate the mechanism in humans. According to BioCentury's BCIQ database, no company is developing LXR...
...26, 2017) . Allison Johnson Myelin VTS-270 Allergan plc Mallinckrodt plc Max Planck Institute Ralexar Therapeutics Inc. Rgenix Inc. Sucampo Pharmaceuticals Inc. Apolipoprotein E (APOE) Liver X receptor (LXR...
BioCentury | Nov 3, 2017
Product Development

Liver X factor

...from an ongoing Phase Ia/Ib study of the small molecule agonist of liver X receptor beta (NR1H2; LXR-b...
...agonizing LXR could treat the disease. Rgenix in-licensed exclusive worldwide rights to RGX-104 and other LXR...
...melanoma metastasis and angiogenesis.” Cell (2012) Emily Cukier-Meisner, Senior Writer Rgenix Inc. Apolipoprotein E (APOE) Liver X receptor (LXR) Liver X receptor beta (NR1H2) (LXR-b) checkpoint...
BioCentury | Nov 3, 2017
Clinical News

Rgenix reports Phase I data for cancer compound RGX-104

...inhibitors. Rgenix has exclusive, worldwide rights to the small molecule inhibitor of liver X receptor beta (NR1H2; LXR-b...
...GlaxoSmithKline plc (LSE:GSK; NYSE:GSK), London, U.K. Product: RGX-104 Business: Cancer Molecular target: Liver X receptor beta (NR1H2; LXR-b...
...and safety; pharmacokinetics Status: Preliminary Phase Ia/Ib data Milestone: NA Chris Lieu RGX-104 GlaxoSmithKline plc Rgenix Inc. Liver X receptor beta (NR1H2) (LXR-b) AACR-NCI-EORTC...
BioCentury | Jun 2, 2017
Product Development

Ears wide open

...by Intrexon Corp. (NYSE:XON); (C) Phase I/II ongoing; JNK = c-jun N-terminal kinase; LXR = liver X receptor...
BioCentury | May 31, 2017
Distillery Techniques

Disease models

...including aryl hydrocarbon receptor (AHR) , constitutive androstane receptor ( NR1I3 ; CAR), liver X receptor (LXR...
...AHR) ATP-binding cassette sub-family A member 1 (ABCA1) Constitutive androstane receptor (NR1I3) (CAR) Cytochrome P450 Epidermal growth factor (EGF) Liver X receptor (LXR) Noggin...
BioCentury | Jan 12, 2017
Clinical News

RGX-104: Ph I started

...Business: Cancer Molecular target: Liver X receptor beta ( NR1H2 ; LXR-b) Description: Small molecule inhibitor of LXR-b...
...PFS) and safety; pharmacokinetics Status: Phase I started Milestone: NA Julian Zhu RGX-104 GlaxoSmithKline plc Rgenix Inc. Liver X receptor beta (NR1H2) (LXR-b...
BioCentury | Jan 11, 2017
Clinical News

Allergan discloses Phase II miss in LXR program

...Phase II trial to treat atopic dermatitis. Allergan acquired the liver X receptor beta ( NR1H2 ; LXR-b...
...orphan receptor C thymus-specific isoform ( RORgamma2 ; RORgammaT). Paul Bonanos VTP-38543 Allergan plc Vitae Pharmaceuticals Inc. Liver X receptor beta (NR1H2) (LXR-b...
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