16:10 , Feb 9, 2018 |  BC Week In Review  |  Clinical News

Madrigal reports Phase II data of MGL-3196 for HeFH

Madrigal Pharmaceuticals Inc. (NASDAQ:MDGL) reported Phase II data for MGL-3196 (VIA-3196) to treat heterozygous familial hypercholesterolemia (HeFH) that, despite meeting the primary endpoint, suggest the candidate would be unable to compete with marketed drugs in...
21:13 , Oct 13, 2017 |  BC Week In Review  |  Clinical News

Athera begins Phase IIa trial of PC-mAb for arterial inflammation

Athera Biotechnologies AB (Stockholm, Sweden) began a Phase IIa trial of once-monthly IV PC-mAb to treat arterial inflammation in patients with elevated levels of lipoprotein(a) (LPA). The double-blind, placebo-controlled, European trial's primary endpoint is monocyte function...
19:54 , Sep 22, 2017 |  BC Week In Review  |  Clinical News

Madrigal completes enrollment in Phase II of MGL-3196 for HeFH

Madrigal Pharmaceuticals Inc. (NASDAQ:MDGL) said it has enrolled 113 patients in a Phase II trial of MGL-3196 (VIA-3196) to treat heterozygous familial hypercholesterolemia (HeFH), exceeding its target enrollment of 105. The company said it would...
22:54 , Sep 14, 2017 |  BC Innovations  |  Targets & Mechanisms

Platelets YAP at cancer

While elevated platelet levels often signify an underlying malignancy, the molecular mechanisms linking the two are not well understood. Now, a team from MD Anderson has shown a well-known, but barely exploited signaling pathway mediates...
19:07 , Jul 14, 2017 |  BC Week In Review  |  Clinical News

Regeneron reports Phase II data for evinacumab in HoFH

Regeneron Pharmaceuticals Inc. (NASDAQ:REGN) reported data from an open-label, international Phase II trial in 9 patients with homozygous familial hypercholesterolemia (HoFH) showing that evinacumab (REGN1500) added to current lipid-lowering therapy reduced mean LDL-C from baseline...
21:06 , Apr 27, 2017 |  BC Week In Review  |  Clinical News

AKCEA-APO(a)-LRx: Ph IIb started

Ionis’ Akcea Therapeutics Inc. subsidiary began a double-blind, placebo-controlled, North American Phase IIb trial to evaluate 5 dose levels of subcutaneous AKCEA-APO(a)-LRx in about 270 patients with hyperlipoproteinemia(a) and established cardiovascular disease. In January, Ionis and...
18:33 , Mar 31, 2017 |  BC Week In Review  |  Company News

Ionis to spin out lipid company Akcea

Ionis plans to spin out subsidiary Akcea Therapeutics Inc. in an IPO in which it would raise up to $100 million. Concurrently, partner Novartis AG (NYSE:NVS; SIX:NOVN, Basel, Switzerland) will invest $50 million in Akcea...
23:50 , Mar 27, 2017 |  BC Extra  |  Financial News

Ionis lipid spinout Akcea targets $100M IPO

Ionis Pharmaceuticals Inc. (NASDAQ:IONS) plans to spin out subsidiary Akcea Therapeutics Inc. in an IPO in which it would raise up to $100 million, according to a regulatory filing. Concurrently, partner Novartis AG (NYSE:NVS; SIX:NOVN)...
21:45 , Feb 1, 2017 |  BC Week In Review  |  Clinical News

Inclisiran: Ph II ORION-2 started

The Medicines Co. began the open-label, Dutch Phase II ORION-2 trial to evaluate 300 mg subcutaneous inclisiran in about 10 patients. Patients whose mean serum PCSK9 levels are not suppressed by >70% at days 60...
19:54 , Jan 13, 2017 |  BC Week In Review  |  Company News

Ionis, Novartis deal

Ionis and its Akcea Therapeutics Inc. subsidiary granted Novartis exclusive, worldwide options to develop and commercialize AKCEA-APO(a)-LRx (IONIS-APO(a)-LRx) and AKCEA-APOCIII-LRx (IONIS-APOCIII-LRx), which are antisense therapies for cardiovascular disorders. Ionis and Akcea will receive an upfront...