BioCentury | Aug 29, 2019
Distillery Therapeutics

Tumor-targeted nanoparticle delivery of gene editing therapy for breast cancer

...DISEASE CATEGORY: Cancer INDICATION: Breast Cancer A tumor-directed nanoparticle delivering CRISPR payloads targeting oncogene LCN2 could...
...breast cancer types -- encompassing an alginate hydrogel surrounding plasmids encoding CRISPR machinery to delete LCN2...
...see "Nanoparticles Targeting CRISPR to Cancer" ). TARGET/MARKER/PATHWAY: Intercellular adhesion molecule-1 (ICAM-1; CD54); lipocalin 2 (LCN2; NGAL...
BioCentury | Aug 28, 2019
Translation in Brief

Nanoparticles targeting CRISPR to cancer

...but not other breast cancer cell types -- encasing plasmids for CRISPR-mediated excision of oncogene LCN2...
...definitely using this approach for other types of cancers,” she added. Targets: LCN2 (NGAL) - Lipocalin 2...
...Intercellular adhesion molecule-1 Sandi Wong, Staff Writer Boston Children's Hospital Harvard Medical School Northeastern University Intercellular adhesion molecule-1 (ICAM-1) (CD54) Lipocalin 2 (LCN2) (NGAL) Breast...
BioCentury | Jan 5, 2019
Finance

Ready to launch

...Duobrii (IDP-118) Plaque psoriasis PDUFA date 2/15/19 BioPorto Diagnostics A/S (CSE:BIOPOR) / Siemens AG (Xetra:SIE) NGAL...
BioCentury | Oct 26, 2018
Politics & Policy

FDA grants first qualification of a clinical safety biomarker

...markers are kidney injury molecule 1 (KIM-1), clusterin (CLU; APOJ), osteopontin (Opn; Spp1), lipocalin 2 (LCN2; NGAL...
BioCentury | Jun 30, 2018
Finance

Eyes on launches

...NYSE:BMY) Zydis rimegepant Acute migraine Top-line Ph II/III BHV3000-201 data 4Q18 BioPorto Diagnostics A/S (CSE:BIOPOR) NGAL...
BioCentury | Jun 14, 2017
Distillery Techniques

Assays and screens

...the LacZ reporter had higher fecal levels of the inflammation biomarker lipocalin 2 ( LCN2 ; NGAL...
BioCentury | Mar 16, 2017
Targets & Mechanisms

Bone appétit!

...showed serum levels of LCN2 inversely correlated with body weight and HbA1c. The findings make LCN2...
...GHSR - Ghrelin receptor GLP-1 - Glucagon-like peptide-1 INSR - Insulin receptor LCN2 (NGAL) - Lipocalin 2...
...al. “MC4R-dependent suppression of appetite by bone-derived lipocalin 2.” Nature (2017) Michael Leviten, Senior Writer Columbia University Lipocalin (NGAL) (LCN2) Obesity...
BioCentury | Mar 15, 2017
Distillery Therapeutics

Endocrine / Metabolic

...Obesity Mouse studies suggest LCN2 could help treat obesity. In a mouse model of obesity, LCN2...
...weight gain compared with vehicle. Next steps include longer-term studies to evaluate the durability of LCN2...
...in the models (see “Bone Appétit.” BioCentury Innovation s (March 16, 2017)). TARGET/MARKER/PATHWAY: Lipocalin (LCN2; NGAL...
BioCentury | Jan 12, 2017
Translation in Brief

Iron age arms race

...by secreting siderophores to recruit iron. The host counters by secreting lipocalin ( NGAL ; LCN2...
...species. While small enough for NGAL to bind, enterobactin has a glycosylated analog, salmochelin, that NGAL...
...Sciences (2016) - Mary Romeo Mary Romeo Massachusetts Institute of Technology University of California Irvine University of Michigan Lipocalin (NGAL) (LCN2) Salmonella...
BioCentury | Dec 13, 2016
Distillery Therapeutics

Hematology

...INDICATION: Hematology Mouse studies suggest an NGAL -enterobactin complex could help treat iron overload caused by...
...testing the NGAL variant-enterobactin complex in additional animal models of iron overload. TARGET/MARKER/PATHWAY: Lipocalin (NGAL; LCN2...
...rstrong@fhcrc.org CONTACT: Andong Qiu, Columbia University, New York, N.Y. email: aq2130@tongji.edu.cn Hongjiang Li University of Washington Lipocalin (NGAL) (LCN2...
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