17:46 , Sep 7, 2018 |  BC Week In Review  |  Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

Twentyeight-Seven Therapeutics Inc. (Cambridge, Mass.) raised $65 million on Sept. 6 in a series A round co-led by MPM Capital and Novartis Venture Fund. Johnson & Johnson Innovation-JJDC Inc., Vertex Ventures HC, Longwood Fund and...
21:22 , Sep 6, 2018 |  BC Extra  |  Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

Twentyeight-Seven Therapeutics Inc. (Cambridge, Mass.) raised $65 million in a series A co-led by MPM Capital and Novartis Venture Fund. Johnson & Johnson Innovation-JJDC Inc., Vertex Ventures HC, Longwood Fund and Astellas Venture Management also...
07:00 , May 19, 2016 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Sirtuin 6 (SIRT6); lin-28 homolog B (LIN28B)

Cancer INDICATION: Pancreatic cancer Patient sample, cell culture and mouse studies suggest inhibiting LIN28B could help treat pancreatic ductal adenocarcinomas (PDACs) harboring loss-of-function SIRT6 mutations. In 30-40% of PDAC patients, SIRT6 levels were lower in...
08:00 , Dec 19, 2013 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Lin-28 homolog A (LIN28A)-dependent metabolic reprogramming for tissue repair Mouse studies suggest elevating LIN28A activity could help promote tissue regeneration after injury or in advanced...
08:00 , Feb 18, 2010 |  BC Innovations  |  Distillery Techniques

Technology: Approach

Approach Summary Licensing status Publication and contact information Drug delivery Nonviral vector for induced pluripotent stem (iPS) cells In vitro and mouse studies suggest that a nonviral DNA vector could be useful for delivering genes...
07:00 , Jun 11, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Lin-28 homolog (LIN28); Lin-28 homolog B (LIN28B) In vitro studies suggest that targeting LIN28 and LIN28B could help treat cancer....
07:00 , Apr 2, 2009 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms Generation of vector-free induced pluripotent stem (iPS) cells A method to generate vector-free iPS cells could improve the clinical utility of...
01:11 , Nov 21, 2007 |  BC Extra  |  Clinical News

Producing hESCs without embryos

Two groups of researchers separately published papers that describe the reprogramming of differentiated human somatic cells to generate cells that resemble human embryonic stem cells (hESCs). In a paper published in Science , researchers from...