...CEO Kazumi Shiosaki told BioCentury. The company’s lead program disrupts the interaction between RNA-binding protein LIN28...
...Twentyeight-Seven Therapeutics, Watertown, Mass. Targets KRAS - K-Ras LET-7 (MIRLET7) - MicroRNA let-7 LIN28 - Lin-28 homolog...
...oncogene homolog SNRP200 - Small nuclear ribonucleoprotein U5 subunit 200 Karen Tkach Tuzman, Associate Editor Twentyeight-Seven Therapeutics Lin-28 homolog (LIN28) MicroRNA...

...let-7 (MIRLET7; LET-7)/lin-28 homolog (LIN28) pathway. MIRLET7, a tumor suppressive miRNA, is antagonized by the protein LIN28...
...which is up-regulated in some cancers. Twentyeight-Seven is aiming to develop small molecule antagonists of LIN28...
...has options to in-license additional IP. The funding will be used to discover and develop LIN28...

...let-7 (MIRLET7; LET-7)/lin-28 homolog (LIN28) pathway. MIRLET7, a tumor suppressive miRNA, is antagonized by the protein LIN28...
...which is up-regulated in some cancers. Twentyeight-Seven is aiming to develop small molecule antagonists of LIN28...
...has options to in-license additional IP. The funding will be used to discover and develop LIN28...

...tumor growth. Next steps include identifying small molecule LIN28B inhibitors. TARGET/MARKER/PATHWAY: Sirtuin 6 (SIRT6) ; lin-28 homolog...

...Approach Summary Licensing status Publication and contact information Drug platforms Lin-28 homolog A (LIN28A)-dependent metabolic reprogramming for...
...of glycolysis and oxidative phosphorylation suppressed hair regrowth. Next steps could include identifying stimulators of Lin28...

...adipose stem cells and fibroblasts were transfected with a single vector containing Oct4, Sox2, Lin-28 homolog (LIN28...

...vitro studies suggest that targeting LIN28 and LIN28B could help treat cancer. Cell lines with LIN28...
...family members and decreased oncogenic transformation compared with control cell lines. In mice, injection of LIN28-expressing...
...injection of control cells. In a screen of human primary tumors and cancer cell lines, LIN28...

...foreskin fibroblasts were transfected with Epstein-Barr virus-based vectors carrying the reprogramming factors OCT4, SOX2, NANOG, LIN28...

...lentiviral transduction of human fibroblasts with genes expressing four transcription factors, Oct4, Sox2, Nanog and Lin28...