BioCentury | Jul 11, 2019
Emerging Company Profile

Twentyeight-Seven’s bet on RNA-binding proteins

...CEO Kazumi Shiosaki told BioCentury. The company’s lead program disrupts the interaction between RNA-binding protein LIN28...
...Twentyeight-Seven Therapeutics, Watertown, Mass. Targets KRAS - K-Ras LET-7 (MIRLET7) - MicroRNA let-7 LIN28 - Lin-28 homolog...
...oncogene homolog SNRP200 - Small nuclear ribonucleoprotein U5 subunit 200 Karen Tkach Tuzman, Associate Editor Twentyeight-Seven Therapeutics Lin-28 homolog (LIN28) MicroRNA...
BioCentury | Sep 7, 2018
Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

...let-7 (MIRLET7; LET-7)/lin-28 homolog (LIN28) pathway. MIRLET7, a tumor suppressive miRNA, is antagonized by the protein LIN28...
...which is up-regulated in some cancers. Twentyeight-Seven is aiming to develop small molecule antagonists of LIN28...
...has options to in-license additional IP. The funding will be used to discover and develop LIN28...
BioCentury | Sep 6, 2018
Financial News

Non-coding RNA company Twentyeight-Seven debuts with $65M

...let-7 (MIRLET7; LET-7)/lin-28 homolog (LIN28) pathway. MIRLET7, a tumor suppressive miRNA, is antagonized by the protein LIN28...
...which is up-regulated in some cancers. Twentyeight-Seven is aiming to develop small molecule antagonists of LIN28...
...has options to in-license additional IP. The funding will be used to discover and develop LIN28...
BioCentury | May 19, 2016
Distillery Therapeutics

Therapeutics: Sirtuin 6 (SIRT6); lin-28 homolog B (LIN28B)

...tumor growth. Next steps include identifying small molecule LIN28B inhibitors. TARGET/MARKER/PATHWAY: Sirtuin 6 (SIRT6) ; lin-28 homolog...
BioCentury | Dec 19, 2013
Distillery Techniques

Technology: Drug platforms

...Approach Summary Licensing status Publication and contact information Drug platforms Lin-28 homolog A (LIN28A)-dependent metabolic reprogramming for...
...of glycolysis and oxidative phosphorylation suppressed hair regrowth. Next steps could include identifying stimulators of Lin28...
BioCentury | Feb 18, 2010
Distillery Techniques

Technology: Approach

...adipose stem cells and fibroblasts were transfected with a single vector containing Oct4, Sox2, Lin-28 homolog (LIN28...
BioCentury | Jun 11, 2009
Distillery Therapeutics

Indication: Cancer

...vitro studies suggest that targeting LIN28 and LIN28B could help treat cancer. Cell lines with LIN28...
...family members and decreased oncogenic transformation compared with control cell lines. In mice, injection of LIN28-expressing...
...injection of control cells. In a screen of human primary tumors and cancer cell lines, LIN28...
BioCentury | Apr 2, 2009
Distillery Techniques

Technology: Drug platforms

...foreskin fibroblasts were transfected with Epstein-Barr virus-based vectors carrying the reprogramming factors OCT4, SOX2, NANOG, LIN28...
BioCentury | Nov 21, 2007
Clinical News

Producing hESCs without embryos

...lentiviral transduction of human fibroblasts with genes expressing four transcription factors, Oct4, Sox2, Nanog and Lin28...
Items per page:
1 - 9 of 9