18:00 , Aug 16, 2017 |  BC Innovations  |  Distillery Therapeutics

Neurology

INDICATION: Parkinson’s disease (PD); neurology Mouse studies suggest electromagnetized nanoparticle-mediated in situ reprogramming of somatic cells into dopaminergic neurons could help treat PD. The reprogramming therapy involves lentiviral vectors encoding the dopaminergic neuron transcription factors ASCL1,...
07:00 , Sep 15, 2016 |  BC Innovations  |  Distillery Techniques

Techniques: Mice with midbrain neuron-specific knockout of LIM homeobox transcription factor 1 α (LMX1A; LMX1) and LMX1B as a model of Parkinson's disease (PD)

Disease models TECHNOLOGY: Transgenics and knockouts LMX1A/LMX1B-knockout mice could be useful for screening therapies to treat PD. In mice, knockout of LMX1A and LMX1B in midbrain dopaminergic neurons recapitulated the oxidative stress in midbrain neurons, high incidence...
07:00 , Jul 28, 2011 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

Approach Summary Licensing status Publication and contact information Drug platforms Generation of induced dopaminergic (iDA) cells from skin fibroblasts A method for generating iDA cells from skin fibroblasts could...
07:00 , May 7, 2009 |  BC Innovations  |  Distillery Techniques

Technology: Drug platforms

This week in techniques Approach Summary Licensing status Publication and contact information Drug platforms LIM homeobox transcription...