BioCentury | May 23, 2017
Distillery Techniques

Disease models

...larval segment A3. In one of the models, three dual LIM domain kinase 1 (LIMK1)/ LIMK2...
...two tool compounds. In a mouse model of fragile X syndrome, one of the dual LIMK1/LIMK2...
...email: akiko.hata@ucsf.edu Hongjiang Li University of California San Francisco Fragile X mental retardation 1 (FMR1) LIM domain kinase 1 (LIMK1) LIM domain kinase 2 (LIMK2)...
BioCentury | Jul 31, 2014
Distillery Therapeutics

Indication: Neurology

...Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain LIM domain kinase 1 (LIMK1); LIMK2...
...inflammation- and heat-induced pain. Rats subjected to both types of pain showed greater Limk1 and Limk2...
...ganglia than controls that did not receive pain stimuli. In rats, plasmid-encoded, dominant-negative Limk1 and Limk2...
BioCentury | Aug 27, 2012
Clinical News

LX7101: Phase I data

...The Woodlands, Texas Product: LX7101 Business: Ophthalmic Molecular target: LIM domain kinase 2 (LIMK2) Description: Small molecule inhibitor of LIM domain kinase 2 (LIMK2)...
BioCentury | Oct 7, 2010
Distillery Therapeutics

Indication: Cancer

...LIM domain kinase 1 (LIMK1); LIMK2 Studies in cell culture suggest that inhibiting LIMK1 and LIMK2...
...In a coculture of squamous carcinoma cells and cancer-associated fibroblasts, addition of a LIMK1 and LIMK2...
...in vivo pharmacological proof-of-concept experiments. SciBX 3(39); doi:10.1038/scibx.2010.1176 Published online Oct. 7, 2010 LIMK1 and LIMK2...
BioCentury | Oct 29, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

...information Ophthalmic disease Glaucoma; ocular hypertension LIM domain kinase 2 (LIMK2) In vitro and mouse studies identified inhibitors of LIMK2...
...of pyrrolopyrimidine compounds selectively inhibited LIMK2. In a mouse model of steroid-induced ocular hypertension, the LIMK2...
...29, 2009 Patent applications pending worldwide for the LIMK2 inhibitors; Lexicon owns the IP; Lexicon's LIMK2...
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