BioCentury | May 23, 2017
Distillery Techniques

Disease models

...muscles 6 and 7 of larval segment A3. In one of the models, three dual LIM domain kinase 1 (LIMK1)/...
...two tool compounds. In a mouse model of fragile X syndrome, one of the dual LIMK1/LIMK2...
...Francisco, San Francisco, Calif. email: akiko.hata@ucsf.edu Hongjiang Li University of California San Francisco Fragile X mental retardation 1 (FMR1) LIM domain kinase 1 (LIMK1) LIM...
BioCentury | Jul 31, 2014
Distillery Therapeutics

Indication: Neurology

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Pain LIM domain kinase 1 (LIMK1); LIMK2 Rat studies suggest...
...help treat inflammation- and heat-induced pain. Rats subjected to both types of pain showed greater Limk1...
...dorsal root ganglia than controls that did not receive pain stimuli. In rats, plasmid-encoded, dominant-negative Limk1...
BioCentury | Aug 27, 2012
Clinical News

LX7101: Phase I data

A double-blind, placebo-controlled, U.S. Phase I trial in 63 patients with glaucoma showed that 0.125% and 0.25% doses of LX7101 for 2 weeks were well tolerated with no serious adverse events or withdrawals due to...
BioCentury | Oct 7, 2010
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Cancer LIM domain kinase 1 (LIMK1); LIMK2 Studies in cell culture suggest that inhibiting LIMK1...
...metastatic cancer. In a coculture of squamous carcinoma cells and cancer-associated fibroblasts, addition of a LIMK1...
...steps include in vivo pharmacological proof-of-concept experiments. SciBX 3(39); doi:10.1038/scibx.2010.1176 Published online Oct. 7, 2010 LIMK1...
BioCentury | Oct 29, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Ophthalmic disease Glaucoma; ocular hypertension LIM domain kinase 2 (LIMK2) In vitro and mouse studies identified inhibitors of LIMK2 that could help treat ocular hypertension....
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